Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 283-911-8 | CAS number: 8016-63-5; 84775-83-7 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Salvia sclarea, Labiatae.
In an acute oral toxicity study, the oral LD50 of test substance was 5600 mg/kg bw with 95 % confidence limits of 5000-6200 mg/kg bw in male rats. (Pre-GLP, Rel. K2)
In an acute oral toxicity study, groups (10 males/dose) of Wistar rats were given a single oral dose of test substance at 4000, 5000, 6250 and 7800 mg/kg bw. Animals were then observed for mortality and clinical signs for 14 days and all survivors were sacrificed for macroscopic examination.
Rats experienced lethargy, diarrhea and urinary incontinence. Deaths occurred overnight following administration of test substance. 1/10, 4/10, 7/10 and 10/10 animals were died at 4000, 5000, 6250 and 7800 mg/kg bw, respectively. In this study, the oral LD50 of test substance was 5600 mg/kg bw with 95 % confidence limits of 5000-6200 mg/kg bw in male rats.
Under the experimental conditions of this study, the test substance is not classified according to Regulation (EC) No. 1272/2008 (CLP) and to GHS.
Based on the available data, the substance is not classified according to the Regulation (EC) No. 1272/2008 as the LD50 is greater than 5000 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again