Registration Dossier
Registration Dossier
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EC number: 204-598-6 | CAS number: 123-07-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Eye Irritation Test (0.1 mL, eyes not rinsed) - no further details reported
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-ethynylphenol
- Cas Number:
- 2200-91-1
- Molecular formula:
- C8H6O
- IUPAC Name:
- 4-ethynylphenol
- Test material form:
- liquid
- Details on test material:
- - Test Material name (as cited in the study): C-979
- Chemical name: 4-ethynylphenol
- Formula: C8H6O
- Description: dark brownish-black liquid
- Date Received: 04.02.1986
- Density: 1.05 g/mL
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no further details stated in the report
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- not rinsed
- Observation period (in vivo):
- 7 d
- Number of animals or in vitro replicates:
- 4
- Details on study design:
- no further details stated in the report
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 7 d
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1.75
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1.25
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3
- Reversibility:
- not fully reversible within: 7 d
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 3.25
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0.25
- Irritant / corrosive response data:
- C-979 produced severe ocular irritation.
All four animals exhibited moderate to severe conjunctival irritation (redness, chemosis, discharge, necrosis), iritis and corneal opacity, stippling and ulceration, at 24 h.
By Day 7, severe irritation was still evident in all animals. - Other effects:
- One animal exhibited a constricted pupil at 24 hours; two animals exhibited pannus (neovascularization of the corneal surface) at Day 7; one animal exhibited hair loss around the eye at Day 7.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Under the conditions of this study, the 4-ethynylphenol is considered to be highly irritating to rabbit eyes.
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