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EC number: 231-836-6 | CAS number: 7758-19-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Dissociation constant
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- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
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- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Nanomaterial pour density
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
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- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Analysis of the test solution was performed, but it was not possible to differentiate from the background.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 122-2 (Algal Toxicity, Tiers I and II)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Cell counts were made during the 96 h test. Temperature of the incubator was measured and recorded daily, and pH was detected in each test vessel at the beginning and end of the test.
- Test organisms (species):
- Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Test temperature:
- 24.5 - 25.3 °C
- pH:
- 7.5 - 7.8
- Nominal and measured concentrations:
- Nominal concentrations used in the preliminary test:0.1, 1, 10, 100 and 1000 mg sodium chlorite/L(Doses are equivalent to 0.075, 0.75, 7.5, 75 and 750 mg chlorite/L)Nominal concentrations used in the actual test:Nominal concentrations were 0 (control), 0.62, 1.25, 2.5, 5.0 and 10.0 mg/L.(Doses are equivalent to 0, 0.46, 0.93, 1.87, 3.73 and 7.5 mg chlorite/L)
- Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 8 other: mg sodium chlorite/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 6 other: mg chlorite/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 6.4 other: mg sodium chlorite/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 5 other: mg chlorite/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.2 other: mg sodium chlorite/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.15 other: mg chlorite/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1 other: mg sodium chlorite/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 95% confidence interval of 0.62 t o1.25 mg/L
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.75 other: mg chlorite/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- Results of the preliminary test:After 96 h the number of cells / mL was less than 50 % of the control value at 10, 00 and 1000 mg/L sodium chlorite and greater than 50 % at all other concentrations.Results of the actual test:Exposure of the algae to sodium chlorite for 96 h resulted in a median effective concentration (EC50) of 1.0 mg/L with a 95% confidence interval of 0.62 to 1.25 mg/L (equivalent to 6 mg chlorite/L). No effects were noted.
- Validity criteria fulfilled:
- yes
- Remarks:
- (according to EU method C.3 the quality criteria are met: The cell density in the control cultures have increased by a factor of at least 16).
- Conclusions:
- Exposure of algae to sodium chlorite for 96 h resulted in a median EC50 of 1.0 mg/L, with a 95% confidence interval of 0.62 to 1.25 mg/L (equivalent to 0.75 mg chlorite/L)
- Executive summary:
The aim of the study was to investigate the toxicity to aquatic algae due to the test material.
The test procedure used was EPA OPP 122-2 (Algal Toxicity, Tiers I and II).
Nominal concentrations used in the preliminary test: 0.1, 1, 10, 100 and 1000 mg sodium chlorite/L (Doses are equivalent to 0.075, 0.75, 7.5, 75 and 750 mg chlorite/L).
The result was as follows:
Exposure of algae to sodium chlorite for 96 h resulted in a median EC50 of 1.0 mg/L, with a 95% confidence interval of 0.62 to 1.25 mg/L (equivalent to 0.75 mg chlorite/L)
Reference
Table A7_4_1_3(2)-5: Cell concentration data
Number of cells/ml x 103 | ||||||
Nominal Concentration (mg sodium chlorite/L) | Replicate | 0 h | 24 h | 48 h | 72 h | 96 h |
0 (control) | 1 | 10 | 42 | 100 | 346 | 1404 |
2 | 10 | 54 | 108 | 428 | 1744 | |
3 | 10 | 46 | 132 | 446 | 1664 | |
mean | 10 | 47 | 113 | 407 | 1604 | |
% control | 100 | 100 | 100 | 100 | 100 | |
0.62 | 1 | 10 | 44 | 104 | 358 | 1484 |
2 | 10 | 56 | 132 | 436 | 1852 | |
3 | 10 | 40 | 110 | 412 | 1316 | |
mean | 10 | 47 | 115 | 402 | 1551 | |
% control | 100 | 100 | 102 | 99 | 97 | |
1.25 | 1 | 10 | 42 | 92 | 156 | 274 |
2 | 10 | 36 | 96 | 236 | 631 | |
3 | 10 | 34 | 110 | 190 | 576 | |
mean | 10 | 37 | 99 | 194 | 494 | |
% control | 100 | 79 | 88 | 48 | 31 | |
2.5 | 1 | 10 | 40 | 108 | 228 | 364 |
2 | 10 | 32 | 112 | 182 | 326 | |
3 | 10 | 34 | 92 | 176 | 296 | |
mean | 10 | 35 | 104 | 195 | 329 | |
% control | 100 | 74 | 92 | 48 | 20 | |
5.0 | 1 | 10 | 44 | 90 | 108 | 138 |
2 | 10 | 22 | 80 | 122 | 212 | |
3 | 10 | 32 | 54 | 60 | 116 | |
mean | 10 | 33 | 75 | 97 | 155 | |
% control | 100 | 70 | 66 | 24 | 10 | |
10.0 | 1 | 10 | 16 | 30 | 12 | 16 |
2 | 10 | 24 | 26 | 24 | 14 | |
3 | 10 | 18 | 16 | 18 | 12 | |
mean | 10 | 19 | 24 | 18 | 14 | |
% control | 100 | 40 | 21 | 4 | 1 |
Description of key information
Key study. The test procedure used was EPA OPP 122-2 (Algal Toxicity, Tiers I and II). The result was as follows: Exposure of algae to sodium chlorite for 96 h resulted in a median EC50 of 1.0 mg/L, with a 95% confidence interval of 0.62 to 1.25 mg/L (equivalent to 0.75 mg chlorite/L
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 1 mg/L
Additional information
Key study. The test procedure used was EPA OPP 122-2 (Algal Toxicity, Tiers I and II). The result was as follows: Exposure of algae to sodium chlorite for 96 h resulted in a median EC50 of 1.0 mg/L, with a 95% confidence interval of 0.62 to 1.25 mg/L (equivalent to 0.75 mg chlorite/L)
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