Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 269-144-1 | CAS number: 68188-18-1
Starting on day 2 after intradermal injection, the control animals exhibiteded red and swollen injection areas. Between day 2 and day 9 these areas opened; this was considered to be a reaction to the intradermal injection of the FCA. Later these areas scabbed and healed. On day 1, all animals receiving the substance showed wounds, swollen, red or partial necrotic injection areas. The stronger reactions, compared to the control animals, was attributed to the test substance's primary irritation. On day 9, after removal of the patch for second induction, the treated' skin on the shoulder area reacted the same in both groups. Therfore it was concluded that the test substance can cause primary dermal irritations, even at concentrations as low as 1%. When challenged with 0.1% test substance no animal showed any irritation reaction or delayed sensitization reaction.
For the assessment of skin sensitization a Guinea Pig Maximation test according to OECD TG 406 is available for the substance. In this study 22 animals were used each for test and for control group. Based on a prior range-finding test the concentrations for the main study were set at 1 % for intradermal and topical induction and at 0.1 % for challenge exposure. The vehicles used were sterile water for the intradermal injections and petrolateum for the topical applications.
After challenge, the test substance was well tolerated by the guinea pigs. Neither irritation reactions nor a potential for delayed skin sensitisation reactions was seen, thus the substance was concluded as having no skin sensitising potential based on this assay.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again