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EC number: 269-144-1 | CAS number: 68188-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- Jan 1970
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation of composition/type of substance insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- Method: single intravenous injection, test substance injected in physiological saline, 4 dose groups, 15 rats/group, observation time 7 days, determination of signs of intoxication, calculation of LD50
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Paraffin oils, sulfochlorinated, saponified
- EC Number:
- 269-144-1
- EC Name:
- Paraffin oils, sulfochlorinated, saponified
- Cas Number:
- 68188-18-1
- Molecular formula:
- typical example: C15H31Na03S
- IUPAC Name:
- n-C14-C17 alkanes, secondary monosulphonic acids, sodium salts
- Details on test material:
- purity not specified
Constituent 1
- Specific details on test material used for the study:
- Information from study report:
Mersolat-Paste (pH 8.25), technical grade
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Kirchborchen, Kreis Paderborn, Germany
- Weight at study initiation: 18-22 g
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- physiological saline
- Details on exposure:
- INJECTION VELOCITY: 1 mL/min
- Doses:
- 100, 150, 200, 250, and 350 mg/kg bw
- No. of animals per sex per dose:
- 15 males
- Details on study design:
- - Duration of observation period following administration: 7 days
- Determination of signs of intoxication - Statistics:
- Calculation of LD50 according to Litchfield and Wilcoxon (J. Pharmacol. Exper. Therap. 96, 99, 1949)
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 195 mg/kg bw
- 95% CL:
- 173.1 - 219.6
- Mortality:
- Mortalities in dose groups: 100 mg/kg 0/15, 150 mg/kg 1/15, 200 mg/kg 8/15, 250 mg/kg 14/15, and 350 mg/kg 15/15. Deaths occurred immediately after injection.
Minimum lethal dose: 150 mg/kg - Clinical signs:
- Animals were severly affected 1 to 10 minutes after injection. Typical signs of intoxication could not be noted. After 3 to 5 hours the animals returned to normal.
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Executive summary:
An LD50 -test was conducted with groups of male mice receiving a single intravenous administration of the test substance at doses of 100 to 350 mg/kg bw in ohysiological saline. The observation time was 7 days. Deaths occurred immediately after injection. The animals were severly affected 1 to 10 minutes after injection. Typical signs of intoxication could not be noted. Surviving animals returned to normal 3 to 5 hours post administration. The LD50 was calculated to be 195 mg/kg bw (95 % confidence level 173.1 -219.6 mg/kg).
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