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EC number: 204-447-4 | CAS number: 121-05-1
With high probability acutely not harmful to fish.
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of the acute toxicity of 2-aminoethyldiisopropylamine (CAS 121-05-1) to fish (Q)SAR results were used. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, and for reasons of animal welfare, further experimental studies on the acute toxicity to fish are not provided.
Experimental data on the toxicity of 2-aminoethyldiisopropylamine (CAS 121-05-1) to fish are not available. Regarding the tonnage band (1 -1000 t/a, intermediate) a study on the short-term toxicity to fish is not required. In order to assess the toxicity to fish, (Q)SAR models were used. The calculated LC50 values are listed for the individual models in the table below. With the exception of the acute toxicity model by VEGA, the substance is within the applicability domain of the models.
Based on a weight-of-evidence approach, 2-aminoethyldiisopropylamine (CAS 121-05-1) is assessed to be with high probability acutely not harmful to fish.
96-h LC50 (mg/L)
QSAR Toolbox v3.3:
96-h LC50 for fish
Prediction based on experimental data for several fish species
Fathead minnow LC50 (96 hr)
(US EPA TEST v4.2.1)
Based on the mean absolute errors of the models the confidence in the predicted results is high for the external test set, while the confidence in the estimated LC50 with regard to the training set is low.
Fathead minnow LC50 96h (EPA)
v1.0.7 (VEGA v1.1.3)
ECOSAR v1.11 (EPI Suite v4.11):
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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