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EC number: 253-523-3 | CAS number: 37482-11-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 96-h LC50 value is 32.3 mg/L for fish (L. idus).
Key value for chemical safety assessment
Additional information
No data on aquatic toxicity is available for sodium 2 -mercaptoethanolate (target chemical). Read across can however be made to 2- mecaptoethanol (CAS 60 -24 -2). The (sodium) 2-mercapthoethanolate ion is a conjugated base, the read across substance 2-mercaptoethanol its undissociated acid. With a pKa value of ca. 9.5 for both substances, in an aqueous environment with pH 7, they will be present almost exclusively as 2-mercaptoethanol. Further, no effects on aqueous toxicity from the sodium cation is to be expected.
Reliable data on the toxicity of 2 -mercaptoethanol to fish is available from two different sources.
The first one describes a short-term fish toxicity study in accordance with DIN 38412 (part 15) (BASF, 1988). In this study groups of 10 golden orfe (L. idus) were exposed to nominal test concentrations of 0 (control), 10, 21.5, 46.4, 100, 215 and 464 mg/L for 96 hours under static conditions. Analysis of test substance stability was performed in a separate test under similar conditions as the fish toxicity test. Based on an arithmetic mean test substance recovery of 54.3%, 'measured concentrations' were determined at 0, 5.4, 11.7, 25.2, 54.3, 116.7 and 251.8 mg/L. Mortality and general symptoms of toxicity were recorded at 1, 4, 24, 48, 72 and 96 h after the start of exposure. Apathy was observed in the 464 mg/L test group after 4 hours exposure. No further symptoms are described at any exposure period or concentration. No mortality was observed up to a analytical concentration of 25.2 mg/L. At an analytical test concentration of 54.3 mg/L all fish died 48 hours after exposure. At higher test concentrations 100% mortality was recorded already after 24 hours exposure. Based on these findings the 96-h LC50 value is determined at 25.2 - 54.3 mg/L or rather 25.2 mg/L as worst case approach. After correction for molecular weight difference (for read-across) the 96 -h LC50 is 32.3 mg/L.
The second one is a report of the Japanese authorities (National Institute of Technology and Evaluation (NITE; former MITI)) of 2010. In this OECD 203 study the toxicity of 2-mercaptoethanol to fish is examined in a 96-h test. Although the used test organisms is not specified, normally in fish toxicity studies performed by the Japanese Authorities orange-red killifish (O. latipes) are used. The 96-h LC50 is reported to be 29 mg/L. After correction for molecular weight difference (for read-across) the 96-h LC50 is 37.2 mg/L.
The BASF study (1988) is considered as key study as it provides the lowest effect concentration for fish. Also, golden orfe are considered to be the most relevant species for European risk assessment.
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