Registration Dossier
Registration Dossier
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EC number: 616-749-7 | CAS number: 79869-59-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- Skin irritation was tested using an internal method. The moistened test substance was applied on the clipped skin on the back (2.5 X 2.5 cm) of 2 animals for a duration of 20 hours. The skin was washed with water which sometimes contained a mild detergent. The animals were observed for 8 days and skin changes were scored after 24, 48, 72h, 6 days and 8 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,10-bis(2-methylpropyl) perylene-3,10-dicarboxylate; 3,9-bis(2-methylpropyl) perylene-3,9-dicarboxylate
- EC Number:
- 616-749-7
- Cas Number:
- 79869-59-3
- Molecular formula:
- C30H28O4
- IUPAC Name:
- 3,10-bis(2-methylpropyl) perylene-3,10-dicarboxylate; 3,9-bis(2-methylpropyl) perylene-3,9-dicarboxylate
- Details on test material:
- - Analytical purity: 100%
- Name of test material (as cited in study report): Fluorolgruengold Misch. Nr. 27-3887
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Average weight at study initiation: 3.56 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- other: untreated parts of the animal skin
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): 50% in water - Duration of treatment / exposure:
- 20 hours
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 20 h
SCORING SYSTEM: internal BASF scoring system that was converted to Draize scores.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 4
- Remarks on result:
- other: Yellow colouring of the skin by the substance prevented scoring of skin changes
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 6d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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