Registration Dossier
Registration Dossier
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EC number: 232-667-0 | CAS number: 9003-98-9
Endpoint summary
Administrative data
Description of key information
Deoxyribonuclease was tested for acute toxicity, including read-across studies.
Fish: Deoxyribonuclease as not tested, however, Alpha-amylase was not toxic at the the tested concentration of 100 mg/L (58.3 mg aep/L) and thus the NOEC was determined to be 100 mg/L (58.3 mg aep/L). The LC50 value could not be determnined due to the absence of toxicity of the test compound at the tested concentration. Due to the similar nature of enzymes, similar results can be expected for the test substance deoxyribonuclease.
Daphnia magna: Exposure of freshwater invertebrate Daphnia magna to the test item has been investigated and gave the following results based on the geometric mean measured test concentrations:
EC50 = 1546 (932 – 2571) mg enzyme concentrate dry matter/L, equivalent to 214 mg active enzyme protein (aep)/L (analytically measured as aep).
NOEC = 852 mg enzyme concentrate dry matter/L.
LOEC = 1704 mg enzyme concentrate dry matter/L.
Algae: Exposure of Raphidocelis subcapitata to the test item gave the following results based on the geometric mean measured test concentrations:
EC50 = 59 (26 – 108) mg enzyme concentrate dry matter/L, equivalent to 8.1 mg active enzyme protein (aep)/L (analytically measured as aep).
NOEC = <5.3 mg enzyme concentrate dry matter/L.
LOEC = ≤5.3 mg enzyme concentrate dry matter/L.
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