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Deoxyribonuclease was tested for acute toxicity, including read-across studies.

For fish: Alpha-amylase was not toxic at the the tested concentration of 100 mg/L (58.3 mg aep/L) and thus the NOEC was determined to be 100 mg/L (58.3 mg aep/L). The LC50 value could not be determnined due to the absence of toxicity of the test compound at the tested concentration. Due to the similar nature of enzymes, similar results can be expected for the test substance deoxyribonuclease.

For crustacean Daphnia magna: Under the conditions of the test, testing of phosphodiesterase batch PPW37486 to Daphnia magna revealed an 48h EC50 value of 32.9 mg/L corresponding to 0.89 mg aep/L. The NOEC (48h) was determined to be 10 mg/L.

For algae: Under the conditions of the test, deoxyribonuclease (phosphodiesterase), batch PPW3748 was found to be slightly toxic to Pseudokirchneriella subcapitata, but no 72h ErC50 could be determined and thus, is> 200 mg/L (5.4 mg aep/L).

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