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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2006
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
no guideline followed
Principles of method if other than guideline:
Visual test
Key result
Medium:
methanol
Solubility:
> 1 000 g/L
Temp.:
40 °C
Key result
Medium:
other: n-hexane
Solubility:
> 1 000 g/L
Temp.:
25 °C

TABLE 1 Solvent solubility test in n-hexane at 25 °C

 

Time

Addition (my)

Sample (my)

n-hexane (mL)

Ratio

(9/1-)

Solution

A

Solution

B

Solution

C

0 h

 

100

0.5

200

clear

clear

clear

24 h at 25 °C

-

100

0.5

200

clear

clear

clear

24.5 h

100

200

0.5

400

clear

clear

clear

25.0 h

100

300

0.5

600

clear

clear

clear

25.5 h

100

400

0.5

800

clear

clear

clear

26.0 h

100

500

0.5

1000

clear

clear

clear

24 h at 25 °C

 

500

0.5

1000

clear

clear

clear

 

TABLE 2 Solvent solubility test in methanol at 25°C

 

Time

Addition (mg)

Sample (mg)

methanol (mL)

Ratio
(g/L)

Solution

A

Solution

B

Solution

C

0 h

 

100

0.5

200

clear

clear

clear

24 h at 25°C

-

100

0.5

200

clear

clear

clear

24.5 h

100

200

0.5

400

clear

clear

clear

25.0 h

50

250

0.5

500

saturated

saturated

saturated

24 h at 25°C

-

250

0.5

500

saturated

saturated

saturated

 

TABLE 3 Solvent solubility test in methanol at 40°C

 

Time

Addition (mg)

Sample (mg)

methanol (mL)

Ratio
(g/L)

Solution

A

Solution

B

Solution

C

0 h

 

250

0.5

500

clear

clear

clear

24 h at 40 °C

-

250

0.5

500

clear

clear

clear

24.5 h

50

300

0.5

600

clear

clear

clear

25.0 h

100

400

0.5

800

clear

clear

clear

25.5 h

100

500

0.5

1000

clear

clear

clear

24 h at 40 °C

-

500

0.5

1000

clear

clear

clear

Conclusions:
For n-hexane the solubility at 25 °C was higher than 1 kg/L.
For methanol the solubility at 25 °C was lower than 1 kg/L, also the effect of the temperature was investigated, obtaining at 40 °C a solubility higher than 1 kg/L.
Executive summary:

In order to investigate the range of solubility for the two solvents, chosen for their polarity difference, two 50 mg aliquots of the test article were weighed by the analytical balance into 10 mL test tubes and 5 mL of each solvent were added.

In both n-hexane and methanol, all the test article was dissolved, indicating a solubility higher than 10 g/L (1% w/w).

Therefore, for both n-hexane and methanol solvents the determination of the test article solubility was performed by a visual test without instrumental analysis.

For n-hexane the solubility at 25 °C was higher than 1 kg/L.

For methanol the solubility at 25 °C was lower than 1 kg/L. However, also the effect of the temperature was investigated, obtaining at 40 °C a solubility higher than 1 kg/L.

Description of key information

A visual test to determine the solubility in organic solvent of the test material has been performed as according to a preliminary test, the solubility was above 10 g/L (1% w/w)

For n-hexane the solubility at 25 °C was higher than 1 kg/L.

For methanol the solubility at 25 °C was lower than 1 kg/L, but also the effect of the temperature was investigated, obtaining at 40 °C a solubility higher than 1 kg/L.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
1 000 g/L

Additional information