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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
5th March 1993 to 1st October 1993
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report Date:
1993

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
Deviations:
no
Qualifier:
according to
Guideline:
other: EEC Directive84/449: Method A7
Deviations:
no
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Solubility in organic solvents / fat solubility
Medium:
standard fat
Solubility:
0.004 other: g/100g fat
Temp.:
37 °C
Test substance stable:
not determined
Details on results:
Solubility in fat was very low whatever parameter (temperature or stirring time) was modified and no significant differences were observed between the results.

Any other information on results incl. tables

Table 1: Fat solubility measurements

Groups

Values

mg/kg

Means

mg/kg

Results

g/1000g

Results

g/100g

Mean

g/100g

Standard deviation

GRA 1-1

1.467

1.197

9.90E-02

9.90E-03

4.49E-03

3.61E-03

GRA 1-1

0.927

GRA 1-2

0.686

0.783

GRA 1-2

0.879

GRA 2-1

0.239

0.265

2.60E-02

2.60E-03

GRA 2-1

0.290

GRA 2-2

0.215

0.255

GRA 2-2

0.294

GRB 1-1

0.228

0.197

2.45E-02

2.45E-03

GRB 1-1

0.165

GRB 1-2

0.304

0.294

GRB 1-2

0.283

GRB 2-1

0.266

0.289

3.02E-02

3.02E-03

GRB 2-1

0.311

GRB 2-2

0.299

0.315

GRB 2-2

0.330

GRA: Group A

GRB: Group B

Applicant's summary and conclusion

Conclusions:
Under the experimental conditions described, the fat solubility was estimated to be 0.00449 g/100 g fat at 37°C.
Solubility in fat was very low whatever parameter (temperature or stirring time) was modified and no significant differences were observed between the results.
Executive summary:

In a general physico-chemical properties study (13193), the fat solubility of the test material was determined to be 0.00449 g/100g fat, according to Method A7 of EEC Directive 984/449 and OECD Guideline 116.