Registration Dossier
Registration Dossier
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EC number: 203-326-3 | CAS number: 105-74-8
Endpoint summary
Administrative data
Description of key information
The substance is not volatile and poorly soluble and these parameters must be taken into account when testing to assess the aquatic toxicity. For this substance, the solubility cannot be determined at the solubility limit and no substance could be measured at the end of any tests conducted. Among the available invalid studies, one performed on Daphnia magna and another one performed on Pseudokirchneriella subcapitata (Gancet, 2008a & b) have been disregarded because the substance is very poorly soluble and may have been lost during the preparation procedure of stock solutions which were filtered prior to cascade dilution. Consequently for both studies, as no analytical verification is possible, it is not known whether the substance was at the saturation limit or not.
All valid studies have been performed at the limit of solubility using a WAF approach with loadings orders of magnitude above the water solubility limit.
In Weber (2010a & b) some measurement was achieved of the WAF loadings although these were actually measurements of the substance dispersed in water not truly dissolved concentrations. For both algae and daphnids, tests were first performed on the substance itself and then a second set of studies was conducted with the same stock solutions as in the first study but aged for seven days prior to exposure in order to test any potential degradation products. After the respective exposure periods of 48 and 72 h, no toxicity was observed to daphnids or algal growth, respectively at any loading tested. Finally, one reliable study is available on Fish (Poecilia reticulate), using a WAF method and again no toxicity was observed up to a WAF loading of 1000 mg/L.
Additional information
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