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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14 June 2016 to 12 July 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Version / remarks:
Deviations from the maximum level of daily mean relative humidity occurred. The study integrity was not adversely affected by the deviation.
Deviations:
yes
Remarks:
Deviations from the maximum level of daily mean relative humidity occurred. The study integrity was not adversely affected by the deviation.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1'-(1-phenylethane-1,1-diyl)bis[4-(heptyloxy)benzene]
EC Number:
811-683-7
Cas Number:
1799707-26-8
Molecular formula:
C34H46O2
IUPAC Name:
1,1'-(1-phenylethane-1,1-diyl)bis[4-(heptyloxy)benzene]

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
Three animals
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality occurred.
Clinical signs:
No clinical signs were noted.
Body weight:
The mean body weight gain shown by the animals over the study period was considered to be normal.
Gross pathology:
No abnormalities were found at macroscopic post mortem examination of the animals.
Other findings:
No findings noted.

Applicant's summary and conclusion

Interpretation of results:
other: EU classification criteria not met
Conclusions:
The oral LD50 of the sunstance in Wistar rats was established to exceed 2000 mg/kg body weight.
Executive summary:

In an acute toxicity study the substance was administered to Wistar rats (3 animals/sex/dose) by oral gavage at a dose level of 2000 mg/kg bw (single administration). There were no mortalities or signs of clinical toxicity, mean body weight gain was comparable with the control animals and no abnormalities found at macroscopic post-mortem examination. The LD50 is 2000 mg/kg bw.