Registration Dossier
Registration Dossier
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EC number: 239-343-8 | CAS number: 15306-17-9
Endpoint summary
Administrative data
Description of key information
The h-CLAT test result is clearly positive and no further investigation is deemed necessary.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Tris (ethyl acetoacetato-O1’,O3) aluminium was tested for its skin sensitisation potential by quantifying changes in the expression level of the two cell surface markers CD86 and CD54 in the THP-1 cells, according to the h-CLAT test protocol, OECD TG 442E. Since the majority result of the three individual runs is positive, the end result of this h-CLAT is considered as “positive”. Tris (ethyl acetoacetato-O1’,O3) aluminium is a potential skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Tris(ethyl acetoacetato-O1',O3)aluminium is skin sensitiser and it is classified H317 according to the CLP Regulation (EC.n.1272/2008). For justification see the results of available studies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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