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EC number: 946-888-1
CAS number: -
Partition coefficient measured for Test
Results of the determination of the test
Measured test item µg
Total nominal quantity of test item
Total quantity of test item
The partition coefficient of the
test item was determined using shake-flask method, in accordante with
the method and procedures outlined into the OECD guideline 107. The
concentration in the aqueous and octanol phases was determined by
HPLC-UV/Vis validate method.
The experiments were carried out applying
volume ratios and quantities of the test substance depending on expected
partition and the LOQ of the analytical method in both phases. The
maximum concentration in either phase was less than 0.01 mol/l. Three
parallel tests were carried out: in the first, the calculated volume
ratio was applied, in the second, this ratio was divided by two and in
the third, this ratio was multiplied by two.
Three replicate samples were prepared at
all solvent ratios. The separation of the two phases was achieved by
centrifugation at 20 °C and the pH of aqueous phases was measured.
The partition coefficient (Pow) of test
item was determined to be 0.3169 ± 0.0701 (95 % confidence interval) at
20 °C and pH ca. 8, which corresponds to log Pow of -0.52 using the
shake flask method.
Quality criteria were met as values of log
Pow derived from individual measurements fell within a range of ± 0.3
logPow: -0.52 at 20 °C and pH ca 8
OECD 107 - shake flask method
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