Registration Dossier
Registration Dossier
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EC number: 308-067-0 | CAS number: 97862-23-2
Endpoint summary
Administrative data
Description of key information
Short term toxicity to fish:
In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the substance is highly insoluble (solubility: < 0.01 mg/L at 25° C) in water. Thus chemical can be considered to be hydrophobic in nature.
Long term toxicity to fish:
In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the substance is highly insoluble (solubility: < 0.01 mg/L at 25° C) in water. Thus chemical can be considered to be hydrophobic in nature.
Short term toxicity to aquatic invertebrates:
In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the substance is highly insoluble (solubility: < 0.01 mg/L at 25° C) in water. Thus chemical can be considered to be hydrophobic in nature.
Long term toxicity to aquatic invertebrates:
In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the substance is highly insoluble (solubility: < 0.01 mg/L at 25° C) in water. Thus chemical can be considered to be hydrophobic in nature.
Toxicity to aquatic algae and cyanobacteria:
Freshwater algal growth inhibition test was carried out on Desmodesmus subspicatus with the substance according to OECD Guideline 201. The stock solution 10 mg/l was prepared by dissolving dark liquid in acetone. Test solutions of required concentration were prepared by mixing the stock solution of the test sample with OECD growth medium and inoculum culture. It was not possibile to test higher concentrations of sample because of low solubilities thus chemical dissolved in the acetone. Test conducted on 0, 0, 2.3, 3.4, 5, 7.4, 10.8 mg/l nominal concentration in static system. Potassium dichromate used as a positive control. ErC50 is calculated from the inhibition of growth rate by non-linear regression using software Prism 4.0, GraphPad. Effects on the growth rate of the organism were studied after the exposure period of 72 hrs. The median effective concentration (ErC50) for the test substance, in Desmodesmus subspicatus was determined to be 15.7 mg/L on the basis of effects on growth rate in a 72 hour study. This value indicates that the substance is likely to be hazardous to aquatic algae and can be classified as aquatic chronic 3 category as per the CLP criteria. The test chemical is as such insoluble in water and hence for the experiment performed the test chemical was dissolved in acetone as the solvent. It is likely that acetone can interfere with the toxicity observed. In natural conditions, the test chemical will be exposed to the test organism in water and as it is insoluble in water, it is less likely to affect the growth of algae and cyanobacteria. Based on the above criteria it can be concluded that the chemical was not toxic and cannot be classified as per the CLP classification criteria.
The test chemical is as such insoluble in water and hence for the experiment performed the test chemical was dissolved in acetone as the solvent. It is likely that acetone can interfere with the toxicity observed. In natural conditions, the test chemical will be exposed to the test organism in water and as it is insoluble in water, it is less likely to affect the growth of algae and cyanobacteria. Based on the above criteria it can be concluded that the chemical was not toxic and cannot be classified as per the CLP classification criteria.
Toxicity to microorganisms:
In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the substance is highly insoluble (solubility: < 0.01 mg/L at 25° C) in water. Thus chemical can be considered to be hydrophobic in nature.
The test chemical is as such insoluble in water and hence for the experiment performed the test chemical was dissolved in acetone as the solvent. It is likely that acetone can interfere with the toxicity observed. In natural conditions, the test chemical will be exposed to the test organism in water and as it is insoluble in water, it is less likely to affect the growth of algae and cyanobacteria. Based on the above criteria it can be concluded that the chemical was not toxic and cannot be classified as per the CLP classification criteria.
Additional information
Short term toxicity to fish:
In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the substance is highly insoluble (solubility: < 0.01 mg/L at 25° C) in water. Thus chemical can be considered to be hydrophobic in nature.
Long term toxicity to fish:
In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the substance is highly insoluble (solubility: < 0.01 mg/L at 25° C) in water. Thus chemical can be considered to be hydrophobic in nature.
Short term toxicity to aquatic invertebrates:
In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the substance is highly insoluble (solubility: < 0.01 mg/L at 25° C) in water. Thus chemical can be considered to be hydrophobic in nature.
Long term toxicity to aquatic invertebrates:
In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the substance is highly insoluble (solubility: < 0.01 mg/L at 25° C) in water. Thus chemical can be considered to be hydrophobic in nature.
Toxicity to aquatic algae and cyanobacteria:
Freshwater algal growth inhibition test was carried out on Desmodesmus subspicatus with the substance according to OECD Guideline 201. The stock solution 10 mg/l was prepared by dissolving dark liquid in acetone. Test solutions of required concentration were prepared by mixing the stock solution of the test sample with OECD growth medium and inoculum culture. It was not possibile to test higher concentrations of sample because of low solubilities thus chemical dissolved in the acetone. Test conducted on 0, 0, 2.3, 3.4, 5, 7.4, 10.8 mg/l nominal concentration in static system. Potassium dichromate used as a positive control. ErC50 is calculated from the inhibition of growth rate by non-linear regression using software Prism 4.0, GraphPad. Effects on the growth rate of the organism were studied after the exposure period of 72 hrs. The median effective concentration (ErC50) for the test substance, in Desmodesmus subspicatus was determined to be 15.7 mg/L on the basis of effects on growth rate in a 72 hour study. This value indicates that the substance is likely to be hazardous to aquatic algae and can be classified as aquatic chronic 3 category as per the CLP criteria. The test chemical is as such insoluble in water and hence for the experiment performed the test chemical was dissolved in acetone as the solvent. It is likely that acetone can interfere with the toxicity observed. In natural conditions, the test chemical will be exposed to the test organism in water and as it is insoluble in water, it is less likely to affect the growth of algae and cyanobacteria. Based on the above criteria it can be concluded that the chemical was not toxic and cannot be classified as per the CLP classification criteria.
The test chemical is as such insoluble in water and hence for the experiment performed the test chemical was dissolved in acetone as the solvent. It is likely that acetone can interfere with the toxicity observed. In natural conditions, the test chemical will be exposed to the test organism in water and as it is insoluble in water, it is less likely to affect the growth of algae and cyanobacteria. Based on the above criteria it can be concluded that the chemical was not toxic and cannot be classified as per the CLP classification criteria.
Toxicity to microorganisms:
In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the substance is highly insoluble (solubility: < 0.01 mg/L at 25° C) in water. Thus chemical can be considered to be hydrophobic in nature.
The test chemical is as such insoluble in water and hence for the experiment performed the test chemical was dissolved in acetone as the solvent. It is likely that acetone can interfere with the toxicity observed. In natural conditions, the test chemical will be exposed to the test organism in water and as it is insoluble in water, it is less likely to affect the growth of algae and cyanobacteria. Based on the above criteria it can be concluded that the chemical was not toxic and cannot be classified as per the CLP classification criteria.
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