Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
QSAR using an accepted calculation method. The assessed substance is within the domain of the QSAR.

Data source

Reference
Reference Type:
other: QSAR
Title:
MPBPVPWIN, v.1.43
Author:
EPA’s Office of Pollution Prevention Toxics and Syracuse Research Corporation.
Year:
2010
Bibliographic source:
http://www.epa.gov/opptintr/exposure/pubs/episuite.htm

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
QSAR calculation
GLP compliance:
no
Type of method:
other: QSAR

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Vapour pressure
Key result
Temp.:
25 °C
Vapour pressure:
0 mm Hg
Remarks on result:
other: Modified Grain Method

Applicant's summary and conclusion

Conclusions:
VP: 1.98E-11 mm Hg.
The vapour pressure was calculated by EpiSuite's MPBPVP model.
Executive summary:

The vapour pressure was calculated by EpiSuite's MPBPVP model and found to be 1.98E-11 mm Hg.

This corresponds to a vapour pressure of 2.64E-9 Pa.

Naphtol AS-OL is considered to be inside the applicability domain of the EpiSuite MPBPVP model since the following criteria are fulfilled:

- the molecular weight of Naphtol AS-OL is within the molecular weight range of the training set

- Naphtol AS-OL has a limited number of functional groups

- all functional groups present in Naphtol AS-OL are represented in the training set and have a fragment coëfficiënt available.