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EC number: 603-547-9 | CAS number: 132123-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-06-23 to 2003-10-01
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study performed according to OECD 305 and METI Guideline: Concentration Test on Chemical Substances in Fish.
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
- Qualifier:
- according to guideline
- Guideline:
- other: METI Guideline: Concentration Test on Chemical Substances in Fish
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Puritiy: 99.78 % (GC)
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals/frequency for test medium samples: days 0, 4, 7, 11, 14, 18, 21, 25, 28, 39, 32, 35, 39, 42
- Vehicle:
- yes
- Details on test solutions:
- According to guideline
PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): HCO-40
- Concentration of vehicle in test medium (stock solution and final test solution(s) at different concentrations and in control(s)): 50 mg/l
Dose 1: Test item: 0.1 mg/L ,
Dose 2: Test item: 0.01 mg/L - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- Cyprinus carpio
Date: 10. Jul 2003
Lot: 030107c
Weight: 7.8 g
Length: 8.7 cm - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 42 d
- Hardness:
- 250 g/L
- Test temperature:
- 25.0 ° +/- 0.4 °C
- pH:
- 7
- Dissolved oxygen:
- saturated
- Nominal and measured concentrations:
- nominal concentration 0.10 mg/L:
Solubilizer used: HCO-40, 50 mg/L
analytically measured concentrations:
day 4: 0.10100 mg/L
day 7: 0.0992 mg/L;
day 11: 0.100 mg/L
day 14: 0.100 mg/L
day 18: 0.0982 mg/L
day 21: 0.0982 mg/L
day 25: 0.100 mg/L
day 28: 0.100 mg/L
day 32: 0.0988 mg/L
day 35: 0.100 mg/L
day 39: 0.100 mg/L
day 42: 0.0992 mg/L
nominal concentration 0.01 mg/L
Solubilizer used: HCO-40, 5 mg/L
analytically measured concentrations:
day 4: 0.00996 mg/L
day 7: 0.00996 mg/L;
day 11: 0.0100 mg/L
day 14: 0.0101 mg/L
day 18: 0.0101 mg/L
day 21: 0.0100 mg/L
day 25: 0.00996 mg/L
day 28: 0.0101 mg/L
day 32: 0.00982 mg/L
day 35: 0.0102 mg/L
day 39: 0.0100 mg/L
day 42: 0.0101 mg/L - Details on test conditions:
- After acclimatisation period, the fish (Cyprinus carpio) were transferred into the test media under flow through conditions. Exposure concentrations were analytically verified at days 0, 5, 14, 21, and 28. The analytical values show that the nominal concentrations of 0.2 and 0.02 mg/L were maintained during the experimental phase.
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.1 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Concentrations maintained using HCO-40
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.1 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Concentrations maintained using HCO-40
- Duration:
- 42 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.1 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Concentrations maintained using HCO-40
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test material showed no toxic potential at concentrations at or above the water solubility. The NOEC was 0.1 mg/L and thus higher than the limit of water solubility.
- Executive summary:
The purpose of this study was to determine the bioconcentration potential of the test material in fish under flow-through conditions. During the GLP compliant test the lethal and other effects in fish were determined during the exposure period of 42 days.
The test material showed no toxic potential at concentrations at or above the water solubility. The NOEC was 0.1 mg/L and thus higher than the limit of water solubility.
Reference
Description of key information
Data from a GLP study according to OECD TG 305 are available.
NOEC (28 d) = 0.10 mg/L (50 mg/L HCO-40)
LC50 (28 d) > 0.10 mg/L (50 mg/L HCO-40)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.1 mg/L
Additional information
NOEC (BCF, 28d) > 0.10 mg/L
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