Registration Dossier
Registration Dossier
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EC number: 215-413-3 | CAS number: 1326-03-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Authorized database
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of CAS no 3520-42-1 in mouse
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of C.I. Acid Red 52 (3520-42-1) in mice
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt
- EC Number:
- 222-529-8
- EC Name:
- Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt
- Cas Number:
- 3520-42-1
- Molecular formula:
- C27H30N2O7S2.Na
- IUPAC Name:
- sodium 4-[3,6-bis(diethylamino)-2,7-dimethylxanthenium-9-yl]benzene-1,3-disulfonate; 2-(3-diethylamino-6-diethylazaniumylidene-xanthen-9-yl)-5-sulfo-benzenesulfonate
- Details on test material:
- - Name of test material:C.I. Acid Red 52
- Molecular formula :C27H30N2O7S2.Na
- Molecular weight :580.6551 g/mole
- Smiles notation: CCN(CC)c1ccc2c(c1)[o+]c3cc(ccc3c2c4ccc(cc4S(=O)(=O)[O-])S(=O)(=O)[O-])N(CC)CC.[Na+]
-InChl:1S/C27H30N2O7S2.Na/c1-5-28(6-2)18-9-12-21-24(15-18)36-25-16-19(29(7-3)8-4)10-13-22(25)27(21)23-14-11-20(37(30,31)32)17-26(23)38(33,34)35;/h9-17H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1
- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material:C.I. Acid Red 52
- Molecular formula :C27H30N2O7S2.Na
- Molecular weight :580.6551 g/mole
- Smiles notation: CCN(CC)c1ccc2c(c1)[o+]c3cc(ccc3c2c4ccc(cc4S(=O)(=O)[O-])S(=O)(=O)[O-])N(CC)CC.[Na+]
-InChl:1S/C27H30N2O7S2.Na/c1-5-28(6-2)18-9-12-21-24(15-18)36-25-16-19(29(7-3)8-4)10-13-22(25)27(21)23-14-11-20(37(30,31)32)17-26(23)38(33,34)35;/h9-17H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1
- Substance type:Organic
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 10300 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 10 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality observed
- Mortality:
- 50% mortality was observed in treated mice at dose 10300 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- the LD50 value was considered to be 10300 mg/kg bw when mice was treated with C.I. Acid Red 52 orally.
- Executive summary:
In a acute oral toxicity study,mice were treated with C.I. Acid Red 52 in the concentration of 10300 mg/kg bw orally. No mortality was observed in treated mice. Therefore,LD50 was considered to be10300 mg/kg bw when mice were treated with C.I. Acid Red 52 orally.
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