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EC number: 202-490-3 | CAS number: 96-22-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Auto flammability
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD Guideline 405 with acceptable restrictions (partly limited documentation; 50 μl instead of 100 μl test substance instilled )
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 50 μl instead of 100 μl test substance instilled
- GLP compliance:
- no
Test material
- Reference substance name:
- Pentan-3-one
- EC Number:
- 202-490-3
- EC Name:
- Pentan-3-one
- Cas Number:
- 96-22-0
- Molecular formula:
- C5H10O
- IUPAC Name:
- pentan-3-one
- Details on test material:
- - Name of test material (as cited in study report): Diaethylenketon
- Physical state: liquid
- Analytical purity: 99.8%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Breeder
- Weight at study initiation: 2,17 - 2.67 kg
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 µL - Duration of treatment / exposure:
- Treatment was once. The eye was left unwashed.
- Observation period (in vivo):
- 8 d
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): not performed
SCORING SYSTEM: Descriptive scores of the raw data have been converted to Draize numerical scores.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8, 7, or 5 days (animal #1, #2 or #3, respectively)
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-48 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no effects
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24-48 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 5, 7, or 5 days (animal #1, #2 or #3, respectively)
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24-48 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
Any other information on results incl. tables
Animal | Reading | Opacity | Iritis | Redness | Chemosis | Comment |
1 | 24 h | 1 | 0 | 1 | 1 | |
2 | 24 h | 1 | 0 | 1 | 1 | |
3 | 24 h | 1 | 0 | 1 | 1 | |
1 | 48 h | 1 | 0 | 1 | 0 | |
2 | 48 h | 1 | 0 | 1 | 0 | |
3 | 48 h | 1 | 0 | 1 | 0 | |
1 | 5 d | 1 | 0 | 0 | 0 | reading after fluorescein application |
2 | 5 d | 1 | 0 | 1 | 0 | |
3 | 5 d | 0 | 0 | 0 | 0 | reading after fluorescein application |
1 | 7 d | 1 | 0 | 0 | 0 | reading after fluorescein application |
2 | 7 d | 0 | 0 | 0 | 0 | reading after fluorescein application |
3 | 7 d | 0 | 0 | 0 | 0 | reading after fluorescein application |
1 | 8 d | 0 | 0 | 0 | 0 | reading after fluorescein application |
mean | 24 - 48 h | 1.00 | 0.00 | 1.00 | 0.50 |
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Executive summary:
In a primary eye irritation study (BASF AG, Department of Toxicology, 1969), 50 µl of undiluted Diethyl ketone was instilled into the conjunctival sac of one eye of 3 White Vienna rabbits. The eyes were not washed out after 24 hours. Animals were observed for 8 days. After 24 hour, slight erythema, slight edema as well as slight corneal opacity were observed. Next observation was made after 48 hours after application. No observation was performed after 72 hours. The mean value of the scores at the 24- and 48-hour reading for erythema, edema, corneal opacity and chemosis calculated overall the animals tested was 1.0, 0.5, 1.0 and 0.0, respectively. The observed changes were fully reversible in all animals within 48 h (edema), 7 days (erythema), and 8 days (corneal opacity).
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