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EC number: 206-534-2 | CAS number: 353-50-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The results of a reliable study showed a 4-hour LC50 around 34.3 ppm. The result was supported by results of other less documented studies indicating that the 4-hour LC50 is below 100 ppm, and the 1-hour LC50 is approx 360 ppm.
Analytical information indicated negligible formation of hydrogen fluoride under the conditions of the study.
Key value for chemical safety assessment
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976-no details
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Principles of method if other than guideline:
- - Principle of test:
the test consists in determining the concentration expected to cause death in 50% of the treated animals.
- Short description of test conditions: 7 groups of rats were exposed to a single exposure of carbonyl fluoride at increasing concentrations for 4 hours to determine the LC50.
- Parameters analysed / observed: mortality, clinical signs, gross pathology - GLP compliance:
- not specified
- Test type:
- traditional method
- Limit test:
- no
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: In-house source, Batch No. 9990
- Expiration date of the lot/batch: no data
- Purity test date: no data
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL: no data - Species:
- rat
- Strain:
- other: ChR-CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 240-260g
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: not specified - Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: cylindrical (12" diameter) Plexiglass chamber
- Exposure chamber volume: 20-liter
- Source and rate of air: 20-liter/minute
- System of generating atmosphere: test atmosphere was generated by syringe driving COF2 into a dilution air stream passing through a Teflon line, and introduced through the top of the 20-liter cylindrical chamber and exhausted through a hole in the bottom of the chamber.
- Treatment of exhaust air: vacuum exhaust, no further details
- Temperature, humidity, pressure in air chamber: 45% humidity (average)
TEST ATMOSPHERE
- Brief description of analytical method used: Infra-red analysis using Miran IR analyser. The method can discriminate HF from COF2, thus allowing to assess the extent of hydrolysis of COF2 to HF.
- Samples taken from breathing zone: no information
VEHICLE
- Composition of vehicle (if applicable): air - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- measured concentrations: 26.7 to 47.6 ppm (v/v) (see result table)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: not specified
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes, gross pathology on 3 rats (basis of selection not provided)
- Other examinations performed: clinical signs - Statistics:
- no data
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 34.3 ppm
- Based on:
- test mat.
- 95% CL:
- >= 23.3 - <= 40.4
- Exp. duration:
- 4 h
- Mortality:
- Reported in the table
- Clinical signs:
- other: Few clinical signs were observed. Rapid shallow to convulsive respiration occurred, varying with exposure concentration.
- Gross pathology:
- Examination of 3 rats (no details on corresponding concentration, and whether they were among the surviving animals):
Observation of white plaques, red focal spots, consolidation and edema of the lungs. Liver congestion and bright red spleens. - Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- The 4-hour acute LC50 for gaseous carbonyl fluoride was determined to be 34.3 ppm (v/v) in air.
- Executive summary:
Carbonyl fluoride was assessed in an acute inhalation toxicity study in rats. Seven groups of 10 males and 10 females were exposed for 4 hours (whole body) to increasing concentrations (26.7 to 47.6 ppm v/v) of carbonyl fluoride to determine the LC50.
Animals were observed for mortality, clinical signs. The gross pathology examination performed on 3 rats (no details on corresponding concentration, and whether they were among the surviving animals) showed white plaques, red focal spots, consolidation and edema of the lungs, liver congestion and bright red spleens.
The LC50 was determined to be 34.3 ppm (v/v) in air.
Reference
Analysis of chamber samples by infrared analysis to discriminate HF from COF2 indicated an average concentration of 48.8 ppm of COF2, with no detection of HF. The rate of hydrolysis to HF was negligible under the test conditions. Thus the acute inhalation toxicity cannot only be attributed to the formation of hydrogen fluoride.
Results :
analytical concentration (TWA) (ppm COF2, v/v) |
sd (ppm COF2, v/v) |
mortality observed (number of dead animals/total in test group) |
26.7 | 4.1 | 5/10 |
30.8 | 3.3 | 3/10 |
32.7 | 1.7 | 3/10 |
41.3 | 6.7 | 6/10 |
44.7 | 6.2 | 8/10 |
47.2 | 4.6 | 9/10 |
47.6 | 6.8 | 6/10 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 92.4 mg/m³
- Quality of whole database:
- The results of a reliable study showed a 4-hour LC50 around 34.3 ppm. The result was supported by results of other less documented studies indicating that the 4-hour LC50 is below 100 ppm.
Additional information
Carbonyl fluoride is predicted to hydrolyse in the presence of water or moisture to hydrogen fluoride and carbon dioxide. However, it seems the acute toxicity of carbonyl fluoride is greater than that of hydrogen fluoride that would be released by hydrolysis.
Pathological examination provided evidence of inflammation and signs of pulmonary oedema following a single administration, indicating that the gas could reach the deeper airways. Focal haemorrhage may be indications of local corrosivity.
Alveolar damages seen following a 1-hour exposure at 360 ppm were reversible (Scheel et al., 1968).
Justification for classification or non-classification
The results of a reliable study showed a 4-hour LC50 around 34.3 ppm. The result was supported by results of other less documented studies indicating that the 4-hour LC50 is below 100 ppm.
Thus the classification for carbonyl fluoride is Acute Toxicity cat. 1, H330: Fatal if inhaled.
There is no sufficient information at non-lethal concentration levels to justify a STOT SE classification.
However, as the acute toxicity observed may be related to the corrosive potential of the hydrogen fluoride expected to be formed from hydrolysis of carbonyl fluoride in the presence of moisture, the supplemental labelling statement EUH071: ‘corrosive to the respiratory tract’ is considered appropriate.
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