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EC number: 205-581-6 | CAS number: 143-06-6
Table 1. Macroscopic observations - Group incidence
Number of Animals: 5
Number examined: 5
- Abnormal area(s)
- No abnormalities detected
In a key Guideline (OECD 402) acute dermal toxicity study, the test material was dermally administered to Sprague-Dawley rats (5/sex/dose) at a single dose of 2000 mg/Kg for a period of 24 hours under semi-occlusive conditions. Post exposure, the adhesive bandage and gauze patch were removed and the treated area (dorsal surface of the trunk of each anima) was cleaned by gentle swabbing of the skin with cotton wool soaked with lukewarm water. The animals were subsequently observed for a period of 14 days. On Day 15, all animals were sacrificed and subjected to gross necropsy examination for both external and internal abnormalities.
No mortality was observed through the study period. Slight to moderate scabs on the treatment site (dorsal region) were observed in several animals from Day 4. These had completely recovered by the end of the observation period in all animals,
with the exception of three females (nos. 1, 3, and 7), that showed scabs on the treatment site also on the day of necropsy.
The body weight changes observed during the study were within the expected range for this species and age of animals. No significant abnormalities were found at necropsy in the animals at termination. Scabs in three female animals (nos. 1, 3 and 7) were observed at the treated site.
These results indicate that the test material has no toxic effects on the rat following dermal exposure over a 24 hour period at a dose level of 2000 mg/Kg. Based on the lack of mortality, the acute dermal LD50 was determined to be >2000 mg/Kg.
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