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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Not enough data for assessment, in Russian language.

Data source

Reference
Reference Type:
publication
Title:
Problem of the toxicity of vanillin
Author:
Makaruk MI
Year:
1980
Bibliographic source:
Gig Sanit, 6, 78-80

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Vanillin
EC Number:
204-465-2
EC Name:
Vanillin
Cas Number:
121-33-5
Molecular formula:
C8H8O3
IUPAC Name:
4-hydroxy-3-methoxybenzaldehyde
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Details on inhalation exposure:
no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
4 months
Frequency of treatment:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
15, 1.5, and 0.5 mg/m3
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Positive control:
no data

Examinations

Observations and examinations performed and frequency:
no data
Sacrifice and pathology:
no data
Other examinations:
no data
Statistics:
no data

Results and discussion

Results of examinations

Details on results:
Long-term inhalation of vanillin at 15.0 mg/m3 affected the nervous and cardiovascular systems and the functional activity of the liver, adrenal
glands, and blood system.
Vanillin at 1.5 mg/m3 is close to the threshold level for activity and at 0.5 mg/m3 is inactive on the systems tested.

Effect levels

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Dose descriptor:
NOAEL
Effect level:
0.001 other: mg/l
Sex:
not specified
Dose descriptor:
LOAEL
Effect level:
0.002 - 11 mg/L air
Sex:
not specified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion