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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Few information are available about the test conditions and the results. Original reference in russian language.

Data source

Reference
Reference Type:
publication
Title:
Problem of the toxicity of vanillin
Author:
Makaruk MI
Year:
1980
Bibliographic source:
Gig Sanit, 6, 78-80

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Vanillin
EC Number:
204-465-2
EC Name:
Vanillin
Cas Number:
121-33-5
Molecular formula:
C8H8O3
IUPAC Name:
4-hydroxy-3-methoxybenzaldehyde
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other:
Details on inhalation exposure:
>>> Generation of the test atmosphere:
* Chamber description:
- Exposure chamber volume: 100 L (no other information are available)
Duration of exposure:
4 h
Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 41.7 mg/m³ air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: rat
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 41.7 mg/m³ air
Based on:
test mat.
Exp. duration:
2 h
Remarks on result:
other: mouse
Mortality:
no mortality was observed
Clinical signs:
other: no data
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LC50 is above 41 mg/m3 which is the value of saturated vapour concentration