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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

Vanillin was investigated for its ready biodegradability in an OECD 301C test over 14 days . The percent biodegradation of the test item was calculated based on the biochemical oxygen demand (BOD) and reached 93% within the 14-day. Consequently, Vanillin was found to be readily biodegradable under the test conditions within 14 days and had no inhibitory effect on the activity of activated sludge microorganisms at the tested concentration of 100 mg/L, which can be used as a NOEC value. 

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
100 mg/L

Additional information

Apart form the key study mentioned above, most of the available data are on single species.

The growth inhibition test on Tetrahymena pyriformis has been selected in supporting study and led to an IC50 (40H) = 163 mg/l (Schultz, 1997).

An EC50 (210 min) = 179 mg/l has been reported on Saccharomyces cerevisiae (Koch et al., 1993) and Microtox tests gave EC50 (5 min) = 57.8 mg/l and EC50 (15 min) = 100.5 mg/l (Cronin et al., 1981; Jin et al., 1999), however these data are not recommended for STP microorganisms risk characterisation.

The only data available on mixed inoculum concerned anaerobic sludge and revealed an EC50 (49H) = 1800 mg/l on methane production inhibition (Sierra-Alvarez & Lettinga, 1991).