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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Description of key information

CIT report (2009) was chosen as key study, since conducted according to OECD guideline and GLP.
Daphnids were exposed to test chemical at nominal concentrations of 0, 5.62, 10, 17.8, 31.6, 56.2 and 100 mg/L for 48 hours in static conditions. Immobilization was observed . The 48 hours EC50 was 36.79 mg/L, and the 48 hours NOEC was 26.8 mg/L.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
36.79 mg/L

Additional information

Only one study on Vanilline was chosen as key study, because it was conducted according to OECD guideline and GLP (CIT, 2009).

Based on the results of this study, Vanilline is considered to be harmful to Daphnia magna.

Another study on Natural Vanillin was chosen as supporting study.

The 48-hours acute toxicity of Natural Vanillin (purity 98%) to Daphnia magna was studied under static conditions. The 48-hours EC50 was higher than 10 mg/L but less than 100 mg/L (based on nominal concentration). 

Based on the results of this study, Natural Vanilline is considered to be harmful to Daphnia magna.