Registration Dossier
Registration Dossier
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EC number: 618-347-7 | CAS number: 9003-01-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report wich meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Acrylic acid
- EC Number:
- 201-177-9
- EC Name:
- Acrylic acid
- Cas Number:
- 79-10-7
- Molecular formula:
- C3H4O2
- IUPAC Name:
- acrylic acid
- Details on test material:
- - Name of test material (as cited in study report): Acrylic acid, pure
- Analytical purity: no data, no stabilizer
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Sodium chloride (0.9%)
- Doses:
- 20, 79, 316, 1260, 2040, 3160, 5010 mg/kg bw
- No. of animals per sex per dose:
- 1 - 5 per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 500 mg/kg bw
- Mortality:
- LD50: approx. 1500 mg/kg bw. At doses of up to 316 mg/kg bw, no mortalities occured.
- Clinical signs:
- other: Signs of toxicity were unspecific after administration of Acrylic acid by gavage: abdominal position.
- Gross pathology:
- No necropsy was performed.
Any other information on results incl. tables
Mortality Dead/Treated |
|||
Dose (mg/kg bw) |
24 h |
48 h |
7 d |
20 |
0/1 |
0/1 |
0/1 |
79 |
0/1 |
0/1 |
0/1 |
316 |
0/1 |
0/1 |
0/1 |
1260 |
1/4 |
1/4 |
1/4 |
2040 |
3/5 |
3/5 |
4/5 |
3160 |
5/5 |
5/5 |
5/5 |
5010 |
1/1 |
1/1 |
1/1 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- A LD50 of ~1500 mg/kg bw was found for acrylic acid when administered orally to rats.
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