Registration Dossier
Registration Dossier
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EC number: 204-354-9 | CAS number: 119-84-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1966
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 956
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Miller, L.C., and Tainter, M.L.: Proc.Soc. Exper.Biol. Med., 57:261.1944
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Coumarin
- EC Number:
- 202-086-7
- EC Name:
- Coumarin
- Cas Number:
- 91-64-5
- Molecular formula:
- C9H6O2
- IUPAC Name:
- 2H-chromen-2-one
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino carworth
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Remarks:
- also corn oil
- Control animals:
- yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 290 mg/kg bw
- Based on:
- dissolved
- Remarks on result:
- other: Dose of coumarin(10% in Propylene Glycol)
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 520 mg/kg bw
- Based on:
- dissolved
- Remarks on result:
- other: Dose of coumarin(6% in corn oil)
Any other information on results incl. tables
Acute toxicity in fasted male albino rats following single oral doses of coumarin in propylene
glycol or corn oil
Rat Groups (10 rats/group 90 grams average body wt) |
Dose of Coumarin(10% in Propylene Glycol) |
%Mortality (at 72hr) |
Dose of Coumarin(10% in corn oil) |
%Mortality (at 72hr) |
Ⅰ Ⅱ Ⅲ Ⅳ Ⅴ Ⅵ Ⅶ |
gm./kgm 0.10 0.20 0.30 0.50 0.70 1.00 1.50 |
0.0 0.0 60.0 100.0 100.0 100.0 100.0 |
gm./kgm 0.25 0.30 0.50 0.60 0.70 0.80 1.00 |
0.0 10.0 40.0 60.0 90.0 70.0 100.0 |
LD50±SD1….. Slope Factor2…. |
|
0.29±0.03gm/kgm 0.16 gm./kgm |
|
0.52±0.03 gm/kgm 0.31 gm./kgm |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
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