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Physical & Chemical properties

Partition coefficient

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Administrative data

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure comparable to standard method and in accordance with general accepted scientific standards; sufficient documentation
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Principles of method if other than guideline:
The log Pow values for two components of Arctium lappa extract (Arctiin and Arctigenin) were determined.
GLP compliance:
not specified
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
-0.21
Remarks on result:
other: pure Arctiin, shaking flask method
Type:
log Pow
Partition coefficient:
1.8
Remarks on result:
other: pure Arctigenin, shaking flask method
Type:
log Pow
Partition coefficient:
-0.2
Remarks on result:
other: pure Arctiin, HPLC method
Type:
log Pow
Partition coefficient:
1.6
Remarks on result:
other: pure Arctigenin, HPLC method
Type:
log Pow
Partition coefficient:
-0.24
Remarks on result:
other: Arctiin in Arctium lappa extract, shaking flask method
Type:
log Pow
Partition coefficient:
1.69
Remarks on result:
other: Arctigenin in Arctium lappa extract, shaking flask method
Conclusions:
The log Pow values were determined to be ca. -0.24 for Arctiin and ca. 1.69 for Arctigenin from the test item Arctium lappa extract by the shake flask method and are in good agreement with values determined for the pure substances.
Executive summary:

The distribution coefficients (octanol/water) for the two main components of Arctium lappa extract (Arctiin and Arctigenin) were determined from pure Arctiin and pure Arctigenin using the shake flask method and the HPLC method. The log Pow for Arctiin and Arctigenin from the test item Arctium lappa extract were determined by the shake flask method.

The log Pow values were determined to be ca. -0.24 for Arctiin and ca. 1.69 for Arctigenin from the test item Arctium lappa extract by the shake flask method.

Log Pow for pure Arctiin as reference substance: -0.21 (shake flask) -0.2 (HPLC)

Log Pow for pure Arctigenin as reference substance: 1.80 (shake flask) 1.60 (HPLC).

Description of key information

The log Pow values were determined to be ca. -0.24 for Arctiin and ca. 1.69 for Arctigenin from the test item Arctium lappa extract by the shake flask method and are in good agreement with values determined for the pure substances.

Key value for chemical safety assessment

Additional information

The log Pow for Arctiin and Arctigenin from the test item Arctium lappa extract were determined by the shake flask method.