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EC number: 249-008-8 | CAS number: 28407-37-6
Table 1: Time of Death Following Dosage
*Specific gravity = 1.299 at 23° Centigrade
Acute oral toxicity study was done in Male and female albino SASCO rats (SASCO strain) weighing 190 to 304 grams .Each animal was examined and only healthy animals were used on this study. The animals were individually housed in metal, wire-bottomed cages elevated above the droppings.Prior to dosing, the animals were fasted overnight.food and water was provided ad libitum.Prior to the actual LD50 determination, exploratory doses were administered to six rats to estimate the order of toxicity of the test material. Based on the results of the preliminary assay, groups of five rats were dosed at levels designed to blanket the toxicity range as follows: 2520, 3170, 3990, 5020 and 6330 mg/kg bw.The test material was prepared as a 50% weight/weight dilution indeionized water. The animals were observed for gross effect at regular intervals on the day of dosing and daily thereafter for 14 days. Animals which succumbed were necropsied. Following the observation period, all surviving animals were weighed, sacrificed and necropsied. The following clinical signs of toxicity were observed Prostration, labored breathing, proneness, malaise, blue-black diarrhea, ptosis, morbidity, lethargy and weakness. These appeared between 45 minutes and 6 hours after dosing .Surviving animals were normal within 6 days after dosing. Final bodyweight records of survivors at termination showed weight gains within expected limits except in one animal at the 5020 mg/kg body weight level which showed no gain. Gross necropsy of animals which succumbed showed generalized congestion of the lung,liver, kidneys and adrenal glands. In all animals, tissues from all major organ systems and muscles were dyed blue to green by the compound. The color level was dose dependent. This dying effect was observed in muscle- and tendon.Gross necropsy of animals sacrificed at termination showed no tissue damage from the administration of the compound except at the 5020 mg/kg body weight dosage. The two animals surviving at this level showed some gross indication of liver damage.Hence, Thelethal concentration (LD50) valuefor acute oral toxicity testwas considered to be3290mg/kg bw,when male and female albino SASCO rats were treated with Copper,[tetrahydrogen-3,3'-[(3,3'-dihydroxy-4,4'-biphenylylene)bis(azo)]bis[5-amino-4-hydroxy-2,7-naphthalenedisulfonato](4-)]di-,tetrasodium salt (7CI) (28407-37-6) orally via gavage.
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