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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
experimental dates: 17 Oct. 2016 to 25 Jan. 2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to OECD guideline, with minor deviations. Test substance is adequately characterised with its purity. However, as a single batch was tested, inter batch variation was not assessed. Therefore validity applies with restrictions.
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Version / remarks:
1981
Qualifier:
according to
Guideline:
EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
Version / remarks:
1996
Qualifier:
according to
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Version / remarks:
2009
Qualifier:
according to
Guideline:
other: CIPAC MT 187 (Particle Size Analysis by Laser Diffraction)
Version / remarks:
2009
GLP compliance:
yes (incl. certificate)
Remarks:
(inspected on 11 & 12 October 2016 / signed on 28 Feb. 2017)
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Percentile:
D10
Mean:
18.6 µm
St. dev.:
0.8
Percentile:
D50
Mean:
184 µm
St. dev.:
4
Percentile:
D90
Mean:
529 µm
St. dev.:
7
No.:
#1
Size:
< 500 µm
Distribution:
88.2 %
No.:
#2
Size:
< 100 µm
Distribution:
33.5 %
No.:
#3
Size:
< 10 µm
Distribution:
5.8 %
No.:
#4
Size:
< 4 µm
Distribution:
1.2 %

From each 3-fold measurement, an average value was calculated. The final result was calculated as mean value from the average values of the two samples.

 

Test series 1

D10
(µm)

D50
(Median diameter, µm)

D90
(µm)

Test 1

19.159

185.921

533.434

Test 2

19.492

191.562

539.576

Test 3

17.506

179.529

529.635

Averaged

18.682

185.658

534.294

 

Test series 2

D10
(µm)

D50
(Median diameter, µm)

D90
(µm)

Test 1

19.164

183.738

530.567

Test 2

18.457

182.196

524.290

Test 3

18.067

182.290

518.094

Averaged

18.555

182.741

524.251

Average of both test series:

D10:         18.6 µm

D50:         184.2 µm       (Median diameter)

D90:         529.3 µm

The results in Volume % passing at 4, 10, 100 and 500 µm:

Particle size /µm

Volume under / %
Average 1

Volume under / %
Average 2

Volume under / %
Mean

4

1.20

1.22

1.2

10

5.75

5.79

5.8

100

33.35

33.70

33.5

500

87.93

88.53

88.2

Conclusions:
The test substance contains a limited fraction of particles fine enough to be inhaled and reach the thoracic fraction.
Dust explosion potential should be considered.
Executive summary:

The granulometry of the test substance was determined under GLP according to ISO13320 and OECD 110 guidelines, with laser diffraction method, in air.

The distribution was a non-symetric Gaussian curve, with a median diameter of 184 μm.

With regard to inhalation potential, about 33.5% of total particles are smaller than 100 μm, and ca 5.8% could reach the thoracic fraction (<10 μm).

Fine particles relevant to dust explosion hazard (<500 μm) account for 88.2%.

Description of key information

Median diameter (D50) = 184 μm

Thoracic fraction (<10 μm) = 5.8 %.

Dust particles (<500 μm) = 88.2 % (dust explosion potential)

Additional information

A reliable experimental study, conducted according to a recognized OECD/ISO guideline, and under GLP, is available. Despite minor restrictions due to measurement of a single batch, it is considered as a key study.