Clemizole hydrochloride

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction

Guideline:

other: REACH Guidance on (Q)SAR

Principles of method if other than guideline:

(Q)SAR

Test organisms (species):

other: Green algae

Test type:

other: (Q)SAR

Water media type:

freshwater

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

0.111 mg/L

Dose descriptor:

other: Chronic Value (ChV)

Effect conc.:

0.05 mg/L

Validity criteria fulfilled:

yes

Remarks:

Imidazoles: Maximum LogKow: 6.4 (Green Algae EC50) - Aliphatic Amines : Maximum LogKow : 7.0 (Green Algae) Chronic Value)

Conclusions:

Estimated EC50 (96h) : 0.11 mg/L
Estimated Chronic Value : 0.05 mg/L
Intermediate substance is estimated to be very toxic to aquatic algae with long lasting effects.

Description of key information

Short-term toxicity:

ECOSAR 1.11: Green Algae: EC50 (96h): 0.111 mg/L

Danish (Q)SAR Database: Pseudokirchneriella s. 72h EC50:

Battery: 20.9 mg/L

Leadscope: 41.7 mg/L

SciQSAR: 0.18 mg/L

 

Long-term toxicity:

Indicated results for chronic toxicity are "Chronic values" as obtained from ECOSAR 1.11

ECOSAR 1.11: Green Algae: ChV: 0.050 mg/L

Key value for chemical safety assessment

EC50 for freshwater algae:

0.11 mg/L

EC10 or NOEC for freshwater algae:

0.05 mg/L

Additional information

NOEC could be estimated to around 0.03 mg/L (ChV/√2) as indicated in Practical Guide 5 - How to use and report (Q)SARs 3.0 (March 2016)

Intermediate substance is estimated to be very toxic to aquatic algae with long lasting effects.