Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-389-7 | CAS number: 106-36-5
This study was conducted to evaluate the sensory irritant potential of inhaled n-propyl propionate vapors in adult Swiss Webster (CFW) mice. The concentration of test material (n-propyl propionate) which resulted in a 50% depression in respiration rate (RD50) was determined according to procedures outlined in ASTM E 981-04 (Standard Test Method for Estimating Sensory Irritancy of Airborne Chemicals).
Groups of four male Swiss Webster (CFW) mice were exposed for thirty minutes to 246, 485, 542, 740, 1214, 3063 or 6793 ppm n-propyl propionate. Mice were allowed a tenminute
acclimation period before the exposure/monitoring cycle began. After the ten minute acclimation period the exposure/monitoring cycle was initiated and baseline respiratory rate data (breaths/minute) were collected for a ten-minute period. Test material exposure was then initiated and mice were exposed for 30 minutes with continuous collection of respiratory rate data. Respiratory rate during a ten-minute recovery period was recorded after the end of exposure.
The mice were held for seven days following exposure during which time body weights and clinical observations were monitored to assess any untoward effects of exposure, with the exception of the 542 ppm exposure group in which these activities were inadvertently not done.
Two animals died during the 6793 ppm exposure (one during the exposure to n-propyl propionate and one during the 10-minute recovery period), one animal died during the 3063 ppm exposure and one animal was found dead on the day following exposure to 1214 ppm. All other animals survived the 30 minute exposure to the test material as well as the one-week post-exposure period. No abnormal in-life observations were noted post-exposure and all surviving mice appeared normal by test day two.
With the exception of the 740 ppm exposure group, which gained weight throughout the study, mean bodyweights for all groups decreased approximately 0.7-7.8% from test day one to test day two. Mean bodyweights for all exposure groups exceeded pre-exposure (test day one) values by the end of the seven-day observation period with the exception of the 6793 ppm exposure group.
Based on these data, the RD50 of inhaled n-propyl propionate is 536 ppm (95% CI = 328- 874) for male Swiss Webster mice.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again