Registration Dossier
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EC number: 946-787-2 | CAS number: -
Toxicity to aquatic plants other than algae
Administrative data
Link to relevant study record(s)
Description of key information
ErC50 frond number, on Lemna minor (7 days) > 91 mg/L
ErC50 dry weight, on Lemna minor (7 days) > 91 mg/L
Key value for chemical safety assessment
- EC50 for freshwater plants:
- 91 mg/L
Additional information
The following data was obtained for the Similar Substance 01. It is expected that the Target substance will present similar effect levels to aquatic plant. Justification for Read Across is given in Section 13 of IUCLID.
The inhibitory effects to Lemna minor were investigated over a period of 7 days, based on the frond number and biomass (dry weight), following the guideline OECD 221. The test item is solid, well soluble (328.5 ± 1.81 g/L at 20.0 ± 0.5°C) and has a purity of 77.1% (active ingredient). The test solutions were prepared by respective dilutions of a stock solution in STEINBERG medium. The test was performed at the nominal test item concentrations of 130, 50.0, 19.2, 7.40 and 2.84 mg/L, corresponding to 100, 38.5, 14.8, 5.69 and 2.19 mg/L of the active ingredient. Three parallel test vessels were used for each test concentration of the test item and six vessels for the blank controls.
The test concentrations during the 7 day test period were determined by HPLC analysis at the beginning of the test, as well as after 3, 5 and 7 days of exposure. These analyses confirmed the right dosage of the test item, but showed that the concentrations of the test item decreased over the whole 7 day test period (91, 86, 61, 76 and 61%, respectively, of the initial value). Therefore, the effective concentrations (ErC50 and EyC50) were assessed based on the geometric mean (GM) of the measured concentrations of the active ingredient. The two endpoints frond number and biomass (dry weight) were investigated at days 3, 5 and 7, and each of them were assessed as growth rate and yield.
In conclusion, the 7 day ErC50 of on Lemna minor was > 91.0 mg/L. This value is based on the geometric mean of the measured concentrations of the active ingredient. The validity criterion was fulfilled.
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