Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Principles of method if other than guideline:
- The reference logPow-values in the OECD-guideline presumably refer to 25 °C. The column temperature was 40 °C. However, the influence of this temperature difference on the calculated logPow value lies within the range of the error of the method.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 1.6
- Temp.:
- 40 °C
- pH:
- 6.2
- Details on results:
- The log Pow value of - 0.4 was calculated with the software KOWWIN v1.66 assuming the nonionic form. KOWWIN is owned by the U.S.Environmental Protection Agency.
- Conclusions:
- The partition coefficient (log Pow) of the test item is 1.6 (100 area % of the test item) at 40 °C estimated by the HPLC method.
- Executive summary:
The partition coefficient (log Pow) of the test item is 1.6 (100 area % of the test item) at 40 °C estimated by the HPLC method according to OECD guideline 117 (Currenta, 2009).
Reference
Description of key information
The partition coefficient (log Pow) of the substance is 1.6 (100 area % of the test item) estimated by HPLC method according to OECD guideline 117 (Currenta, 2009).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.6
- at the temperature of:
- 40 °C
Additional information
The HPLC method enables partition coefficients to be estimated in the log Pow range between 0 and 6. This method, however, is not applicable to strong acids and bases, metal complexes, substances which react with the eluent, or surface-active agents. Measurements should be made on ionisable substances in their non-ionized from (free acid or free base), using only an appropriate buffer with a pH below the pK for a free acid or above the pK for a free base. The pKa value is 14.02 ±0.10 (calculated with the software ACD/pKa v 7.0 at a simplified structure of the test item). Therefore the undissociated form (protonated form) exists at a pH value < 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
