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Partition coefficient

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Description of key information

The partition coefficient (log Pow) of the substance is 1.6 (100 area % of the test item) estimated by HPLC method according to OECD guideline 117 (Currenta, 2009).

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
40 °C

Additional information

The HPLC method enables partition coefficients to be estimated in the log Pow range between 0 and 6. This method, however, is not applicable to strong acids and bases, metal complexes, substances which react with the eluent, or surface-active agents. Measurements should be made on ionisable substances in their non-ionized from (free acid or free base), using only an appropriate buffer with a pH below the pK for a free acid or above the pK for a free base. The pKa value is 14.02 ±0.10 (calculated with the software ACD/pKa v 7.0 at a simplified structure of the test item). Therefore the undissociated form (protonated form) exists at a pH value < 13.