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EC number: 931-515-7
CAS number: 1334422-18-2
In an in-vivo micronucleus assay, five male
and five female B6C3F1 mice were exposed nose only for six hours/day for
ten consecutive days to 1000 ppm of MRD 92-321 (C6 alkene) in air. The
positive control, cyclophosphamide in water, was administered via oral
gavage at a dose of 40 mg/kg, while air served as the negative control.
Bone marrow samples were collected at approximately 24 hours after the
last exposure and evaluated for micronucleus formation.
MRD 92-321 did not induce a statistically
significant decrease in the mean percent of polychromatic erythrocytes
which is a measure of bone marrow toxicity. The test material also did
not induce a statistically significant increase in the mean number of
micronucleated polychromatic erythrocytes. The positive and negative
control gave appropriate results. Based on these results, the test
material is not clastogenic to the bone marrow of the B6C3F1 mouse.
This study received a Klimisch score of 2
and is classified as “reliable with restrictions” because though this
study did not specify the use of GLP guidance it was conducted in close
accordance to OECD TG 474.
study was selected as a supporting study because …………………]
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