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EC number: 931-515-7 | CAS number: -
In an acute inhalation toxicity study, a limit test was first performed on a group of 10 young male adult Sprague-Dawley rats. The animals were exposed to 87.5 mg/L of 1-octene for one hour. After one hour of exposure nine out of ten animals were found dead. Following the limit test a four hour LC50 inhalation toxicity study was performed on 6 groups, 10 per group, of male Sprague-Dawley rats which were exposed to 1octene, whole body, by inhalation route for four hours (vapour atmosphere) at exposure concentrations of 28.0, 31.1, 36.0, 40.5, 48.4, and 53.6 mg/L. Based on the results study authors concluded that the LC50 for 1-octene in male Sprague-Dawley rats for a four hour exposure period is 8050 parts per million, with a 95% confidence interval of 6600-9800 parts per million.
This study was given a Klimisch score of 2 and was classified as reliable with restrictions because while this study predates GLP guidance, the limited information provided indicates that this study was conducted in a manner similar to OECD 403 guideline.
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