Registration Dossier
Registration Dossier
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EC number: 229-213-9 | CAS number: 6429-04-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- TETRAHYDRO-PAPAVERINE AND HOMODIHYDRO-PAPAVERINE ON BLOOD PRESSURE Effect Of
- Year:
- 1 964
- Bibliographic source:
- Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 200
Materials and methods
- Principles of method if other than guideline:
- method not available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolinium chloride
- EC Number:
- 229-213-9
- EC Name:
- 1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolinium chloride
- Cas Number:
- 6429-04-5
- Molecular formula:
- C20H25NO4.ClH
- IUPAC Name:
- 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium chloride
- Test material form:
- solid: particulate/powder
1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 700 mg/kg bw
Applicant's summary and conclusion
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