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Short-term toxicity to aquatic invertebrates

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Description of key information

48h-EC50 (Daphnia magna, mortality) > 0.03 mg/L (measured), 48h-EC50 (Daphnia magna, mortality) > 100 mg/L (nominal; supersaturated solution), 48h-EC0 (Daphnia magna, mortality) >= 0.03 mg/L (measured) and 48h-EC0 (Daphnia magna, mortality) >= 100 mg/L (nominal; supersaturated solution)

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Acute toxicity to aquatic invertebrates was investigated in a reliable key study according to OECD 202 and in compliance with GLP (RCC, 2000, RL1). As the test item was highly insoluble in water, a limit test was performed with a supersaturated solution prepared at 100 mg/L test item and filtered through 1.2 µm glass wool filter. Test concentrations were analytically verified. During exposure, no immobility or mortality was observed. No other symptoms of intoxication were observed (sublethal effects). In conclusion, the test item showed no sign of acute toxicity to Daphnia magna above the maximum water solubility of the test item. Derived effect concentrations were: 48h-EC50 > 0.03 mg/L (measured), 48h-EC50 > 100 mg/L (nominal; supersaturated solution), 48h-EC0 >= 0.03 mg/L (measured) and 48h-EC0 >= 100 mg/L (nominal; supersaturated solution).