Registration Dossier
Registration Dossier
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EC number: 292-053-3 | CAS number: 90530-15-7
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Test substance appears to be hydrolytically stable at room temperature.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 2 107 h
- at the temperature of:
- 50 °C
Additional information
A study was conducted to determine hydrolysis as a function of pH for the test substance according to OECD Guideline 111 and EU Method C.7, in compliance with GLP. The study comprised of the pre-test at 50°C with buffers at pH 4, 7 and 9 for the duration of 5 d. Significant decomposition was observed of test substance at pH 4, 7 and 9; less than 87% (pH 4), 85% (pH 7) and 81% (pH 9) of the original concentration was measured (Sárvári Z, 2014d). Hence the higher tier test was required at these pH values. In the tier 2 test, the hydrolysis was studied at 25, 50 and 67°C with buffers at pH 4, 7 and 9. At 25°C, the test substance concentration observed at the end of study period was 80% (pH4), 88% (pH 7) and 111% (pH 9) of the initial test substance concentration. At 50°C, the test substance concentration observed at the end of study period was 68% (pH4), 73% (pH 7) and 81% (pH 9) of the initial test substance concentration. At 67°C, the test substance concentration observed at the end of study period was 31% (pH4), 66% (pH 7) and 47% (pH 9) of the initial test substance concentration. Hence, based on the decomposition data, the test substance was found to be hydrolytically stable. The measured values were highly variable and no correlation can be seen between expired time and decrease of concentration. Only at 67°C significant correlation between the time and the decrease of concentration of test substance was observed. Under the test conditions, test substance appears to be hydrolytically stable at room temperature. The hydrolysis half- life was determined to be 2,107 h (88 d) at 50°C and pH 7 (Sárvári Z, 2015a).
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