Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 216 (Soil Microorganisms: Nitrogen Transformation Test)
- GLP compliance:
- yes
- Test organisms (inoculum):
- soil
- Total exposure duration:
- 28 d
- Nominal and measured concentrations:
- 1000 mg/kg.
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- nitrate formation rate
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- nitrate formation rate
- Details on results:
- An increase (36%) in nitrogen transformaiton activity was observed - i.e. a positive effect compared to the controls.
- Conclusions:
- The effect on the nitrogen transformation activity of soil micro-organisms was investigated over a 28 day period and gave an EC50 value of greater than 1000 mg/kg and a NOEC of 1000 mg/kg.
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: read across from K1 study
- Reason / purpose for cross-reference:
- read-across source
- Test organisms (inoculum):
- soil
- Total exposure duration:
- 28 d
- Nominal and measured concentrations:
- 1000 mg/kg.
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- nitrate formation rate
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- nitrate formation rate
- Details on results:
- An increase (36%) in nitrogen transformaiton activity was observed - i.e. a positive effect compared to the controls.
- Conclusions:
- The effect on the nitrogen transformation activity of soil micro-organisms was investigated over a 28 day period and gave an EC50 value of greater than 1000 mg/kg and a NOEC of 1000 mg/kg.
Referenceopen allclose all
Description of key information
Soil micro-organism toxicity (carbon transformation): NOEC 1000 mg/kg
Soil micro-organism toxicity (nitrogen transformation): NOEC 1000 mg/kg
Key value for chemical safety assessment
- Short-term EC50 for soil microorganisms:
- 1 000 mg/kg soil dw
- Long-term EC10 or NOEC for soil microorganisms:
- 1 000 mg/kg soil dw
Additional information
OECD Guideline 216 (Soil Microorganisms: Nitrogen Transformation Test):
The effect on the nitrogen transformation activity of soil micro-organisms was investigated over a 28 day period and gave an EC50 value of greater than 1000 mg/kg and a NOEC of 1000 mg/kg.
OECD Guideline 217 (Soil Microorganisms: Carbon Transformation Test):
The effect on the carbon transformation activity of soil micro-organisms was investigated over a 28 day period and gave an EC50 value of greater than 1000 mg/kg and a NOEC of 1000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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