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EC number: 435-790-1 | CAS number: 297730-93-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EU method B.4 (Acute Toxicity: Dermal Irritation/Corrosion
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- T-7145
- IUPAC Name:
- T-7145
- Details on test material:
- - Name of test material (as cited in study report: T-7145
- Physical state: Clear colorless liquid
- Analytical purity: Expected to be > 99.5%
- Lot/batch no.: Lot 4
- Expiration date of the lot/batch: April 28,2000
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Sex: male
TEST ANIMALS
- Source: Charles River Deutschland
- Age at study initiation: at least 6 weeks
- Weight at study initiation: 1732, 1668, 1601 grams
- Housing:- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approx 21 C
- Humidity (%): approx 50%
- Air changes (per hr): approx 15
- Photoperiod (hrs dark / hrs light): 12 hour dark/12 hour light
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): applied undiluted - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 150 square centimeters
- Type of wrap if used: 2 x 3 cm patch
REMOVAL OF TEST SUBSTANCE
- Washing (if done): water
- Time after start of exposure: 4 hours after application
SCORING SYSTEM: 0 - 4 erythema and eschar formation; 0 - 4 edema formation
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- other: 4 hours
- Score:
- 0
- Irritant / corrosive response data:
- No signs of skin irritation, corrosion, skin coloring or toxicity was observed .Scores of 0 were noted at all timepoints.
Any other information on results incl. tables
No signs of skin irritation, corrosion, skin coloring or toxicity was observed .Scores of 0 were noted at all timepoints.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No skin irritation was observed at any time point in any of the animals. According to EC criteria in Guidelines in Commission Directive 93/21/EEC, the test material does not have to be classified and has no obligatory labelling requirement for skin irritation.
- Executive summary:
Primary skin irritation study with the test material in the rabbit (4 hour semi-occlusive application) was conducted. Three rabbits were exposed to 0.5 ml of test material, applied onto clipped skin for 4 hours using a semi-occlusive dressing. Observations were made at 1, 24, 48 and 72 hours after exposure. No skin irritation was observed at any time point in any of the animals. According to EC criteria in Guidelines in Commission Directive 93/21/EEC, the test material does not have to be classified and has no obligatory labelling requirement for skin irritation.
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