Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1989
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1989

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Analytical purity: 97%
- Source: Aldrich Chemical Company, Milwaukee, WI, USA

Results and discussion

Applicant's summary and conclusion

Conclusions:
Based on this ex vivo study, it can be concluded that succinonitrile can be metabolized to cyanide in the nasal tissue and -to a lesser extent- in the liver.
Executive summary:

In a microsomal enzyme assay it was shown that succinonitrile is metabolized to cyanide. Microsomal fractions from both nasal and liver preparations actively metabolized succinonitrile to cyanide.