Registration Dossier
Registration Dossier
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EC number: 234-186-1 | CAS number: 10584-98-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The following was provided as the key study for the endpoint Toxicity to aquatic algae and cyanobacteria:
Odersma. H, Hanstveir. A.O, & de Haan. H.P.M (2004) Dibutyltin bis (2-ethy1hexylmercaptoacetate) (CAS# 10584-98-2 DBT(EHMA)): Determination of the effect on the growth of the fresh water green alga Scenedesmus subspicatus. Testing Laboratory: TNO Physiological Sciences, Location Zeist, Utrechtsweg 48, P.O. Box 360, 3700 AJ Zeist, The Netherlands. Owner Company: Organotin Environmental Programme (ORTEP) Association Stabilizer. Report No.: 010.45228/01.30. Report date: 2004-06-02.
The study was assigned a reliability score of 2 and considered suitable for assessment. The study was performed in compliance with GLP and according to the guideline OECD 201.
A further study was provided as supporting information:
Grade R (1993) Growth Inhibition Test of Irgastab T 22 M to Green Algae (Scenedesmus subspicatus). Testing Laboratory: Ciba-Geigy Ltd. Product Safety Ecotoxicology, R-1066.P, CH-4002 Basel, Switzerland. Owner company: Ciba-Geigy Ltd, AD - Division, CH-4002 Basel, Switzerland. Report No.: 928292. Report date: 1993-04-26
The study was provided as supporting information only as the test material on which the study was performed contained 65% of the substance of interest. The study was assigned a reliability score of 2.
Key value for chemical safety assessment
Additional information
Odersma. H, Hanstveir. A.O, & de Haan. H.P.M (2004) was submitted as the key study to fulfil the data requirement. The study was performed in accordance with the OECD guideline 201, in compliance with GLP. The study was assigned a reliability score of 2 and considered reliable and adequate for assessment.The toxicity of dibutyltin bis (2-ethylhexylmercaptoacetate) to the fresh water green algaScenedesmus subspicatuswas determined in a 72-h growth inhibition. The NOEC was ≥120 µg Sn/L, equivalent to ≥646 µg DBT(EHMA)/L. The ErC50 value was >120 µg Sn/L, equivalent to >646 µg DBT(EHMA)/L. The EbC50 value was >120 µg Sn/L, equivalent to >646 µg DBT(EHMA)/L.
Grade R (1993) was provided as the supporting study. The study was performed in compliance with GLP to a good scientific standard; accordingly the study was assigned a reliability score of 2. The acute toxicity to Green Algae (Scenedesmus subspicatus) was assessed in a 72 hour Algal inhibition test. The final measured concentrations tested were 0, 0.19, 0.29, 0.63, 1.1 and 2.5 mg/L. The EC50 (48 h) found to be 0.56 mg/L with 95 % confidence limits of 0.44 and 0.70 mg/L.
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