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EC number: 617-606-1 | CAS number: 84656-75-7
After a single application to the intact dorsal skin of rabbits, for a 4 hours period of exposure under semiocclusive conditions, no signs of irritation were observed in the treated areas. No signs of clinical toxicity were detected.
All animals survived the observation period.
Body weight development of the treated rabbits was inconspicuous.
The purpose of this assay was to identify the skin irritation/corrosion potential of the test item when applied to the intact skin of previously shaven rabbits for a 4 hours period under semiocclusive conditions. This study should provide a rational basis for risk assessment to the irritating potential of the test item in man.
To test for primary skin irritation, the test item was mixed with some drops of Aqua pro injectione to ensure good contact to the skin. Afterwards the test material was spread onto patches and applied to the intact skin of three previously shaven rabbits for a 4 hours period under semiocclusive conditions. The first examination of the treated skin sites followed 1 hour after removal of the patches. Then, examinations were performed daily for further 7 days.
Under the conditions of the present study no signs of irritation were seen. The evaluation of all animals yields a zero mean score.
The test item was not irritating to the skin in this assay. According to the Regulation 1272/2008 the test material should not be classified as a skin irritant.
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