2-Naphthalenol, 1-[[4-(phenylazo)phenyl]azo]-, ar-heptyl ar',ar''-Me derivs.

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
According to the water solubility estimates in EPISuite (V.1.43), the water solubility of the test material was estimated to range from 1.4 x 10-8 to 1.8 x10-7 mg/L, and the Log Kow (EPISuite Kowwin v 1.68) was estimated to range from 11.7 to 12.8. These estimated data were supported by empirical water solubility and n-octanol/water partition coefficient data of < 5.0 x 10-5 g/L at 20.0 °C and greater than 3.16 x 106 (log Pow > 6.5), respectively.
Using the ECOSAR program (developed by the US Environmental Protection Agency’s Office of Chemical Safety and Pollution Prevention, v 1.11), the predicted effect levels for both acute and chronic endpoints with daphnids exceeded the estimated water solubility by more than 10X for the chemical structures evaluated. Thus, no acute or chronic toxicity effects at water saturation were predicted for the test material, and the study was deemed scientifically not necessary.

Description of key information

No acute or chronic toxicity effects at water saturation were predicted for the test material, therefore acute testing with aquatic invertebrates is waived since the study is scientifically not necessary.