Registration Dossier
Registration Dossier
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EC number: 257-151-2 | CAS number: 51357-74-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Fiber Reactive Dyes Toxicological Profiles December 1981
- Author:
- U.S. Consumer Product Safety Commission
- Year:
- 1 981
- Bibliographic source:
- Fiber Reactive Dyes Toxicological Profiles December 1981,PB83-168732
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess skin irritation potential of, 1-Amino-4-(2'-(4'',6''-dichloro-s-triazin-2-yl)amino)phenylamino)9,10-dihydro-9,10-dioxoanthracene-2,4'-disulphonic acid on rabbit eye
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-amino-4-(2'-(4',6'-dichloro-s-triazin-2-yl)amino)phenylamino)9,10-dihydro-9,10-dioxoanthracene-2,4'-disulphonic acid
- EC Number:
- 236-363-9
- EC Name:
- 1-amino-4-(2'-(4',6'-dichloro-s-triazin-2-yl)amino)phenylamino)9,10-dihydro-9,10-dioxoanthracene-2,4'-disulphonic acid
- Cas Number:
- 13324-20-4
- Molecular formula:
- C23H14Cl2N6O8S2
- IUPAC Name:
- 1-amino-4-({3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfophenyl}amino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report):Procion blue MX-R
- Molecular formula :C23H14Cl2N6O8S2
- Molecular weight :637.436 g/mol
- Substance type:organic
-Physical state: solid
InChI:1S/C23H14Cl2N6O8S2/c24-21-29-22(25)31-23(30-21)28-12-7-9(5-6-14(12)40(34,35)36)27-13-8-15(41(37,38)39)18(26)17-16(13)19(32)10-3-1-2-4-11(10)20(17)33/h1-8,27H,26H2,(H,34,35,36)(H,37,38,39)(H,28,29,30,31)
Smiles:c12c(C(c3ccccc3C2=O)=O)c(c(S(O)(=O)=O)cc1Nc1cc(c(S(O)(=O)=O)cc1)Nc1nc(nc(n1)Cl)Cl)N
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Procion blue MX-R
- Molecular formula :C23H14Cl2N6O8S2
- Molecular weight :637.436 g/mol
- Substance type:organic
-Physical state: solid
InChI:1S/C23H14Cl2N6O8S2/c24-21-29-22(25)31-23(30-21)28-12-7-9(5-6-14(12)40(34,35)36)27-13-8-15(41(37,38)39)18(26)17-16(13)19(32)10-3-1-2-4-11(10)20(17)33/h1-8,27H,26H2,(H,34,35,36)(H,37,38,39)(H,28,29,30,31)
Smiles:c12c(C(c3ccccc3C2=O)=O)c(c(S(O)(=O)=O)cc1Nc1cc(c(S(O)(=O)=O)cc1)Nc1nc(nc(n1)Cl)Cl)N
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- not specified
- Duration of treatment / exposure:
- not specified
- Observation period:
- not specified
- Number of animals:
- not specified
- Details on study design:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: not specified
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No skin irritation reactions were observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritatting
- Conclusions:
- 1-Amino-4-(2'-(4'',6''-dichloro-s-triazin-2-yl)amino)phenylamino)9,10-dihydro-9,10-dioxoanthracene-2,4'-disulphonic acid when applied in rabbit skin produced no skin irritation reactions. Hence, 1-Amino-4-(2'-(4'',6''-dichloro-s-triazin-2-yl)amino)phenylamino)9,10-dihydro-9,10-dioxoanthracene-2,4'-disulphonic acid was considered to be not irritating to rabbit skin.
- Executive summary:
1-Amino-4-(2'-(4'',6''-dichloro-s-triazin-2-yl)amino)phenylamino)9,10-dihydro-9,10-dioxoanthracene-2,4'-disulphonic acid was used as a test material to evaluate skin irritation potential .
No skin irritation reactions were observed . Hence, 1-Amino-4-(2'-(4'',6''-dichloro-s-triazin-2-yl) amino)phenylamino) 9,10-dihydro-9, 10-dioxoanthracene-2,4'-disulphonic acid was considered to be not irritating to rabbit skin.
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