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Hydrolysis

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical Sodium 4-{[4-(diethylamino)phenyl][4-(diethyliminio)-2,5-cyclohexadien-1-ylidene]methyl}-6-hydroxy-1,3-benzenedisulfonate can be expected to be > 1 yr at pH 4, 7 and 9 & at a temperature of 50⁰C and the hydrolysis rate constant can be 4.31e-11 cm3/mol/sec indicating negligible hydrolysis.Thus, based on this half-life value, it can be concluded that the test chemical Sodium 4-{[4-(diethylamino)phenyl][4-(diethyliminio)-2,5-cyclohexadien-1-ylidene]methyl}-6-hydroxy-1,3-benzenedisulfonate is not hydrolysable.

Additional information

Hydrolysis

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical Sodium 4 -{[4 -(diethylamino)phenyl][4 -(diethyliminio)-2,5 -cyclohexadien-1-ylidene]methyl}-6-hydroxy-1,3-benzenedisulfonate.The studies are as mentioned below:

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9 & at a temperature of 50⁰C with a corresponding half-life of > 1 years, respectively. Based on this, it is concluded that test chemical is not expected to undergoe hydrolysis under environmental test conditions and thus can be considered to be not hydrolysable.

The hydrolysis rate conatant of test chemical estimated was 4.31e-11 cm3/mol/sec as this hydrolysis rate constant is very less this chemical shows negligible hydrolysis and it is also supported by data obtained from authoritative database ( HSDB) that this chemical lack hydrolyzable functional group and does not undergo hyrolysis.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical Sodium 4-{[4-(diethylamino)phenyl][4-(diethyliminio)-2,5-cyclohexadien-1-ylidene]methyl}-6-hydroxy-1,3-benzenedisulfonate can be expected to be > 1 yr at pH 4, 7 and 9 & at a temperature of 50⁰C and the hydrolysis rate constant can be 4.31e-11 cm3/mol/sec indicating negligible hydrolysis.Thus, based on this half-life value, it can be concluded that the test chemical Sodium 4-{[4-(diethylamino)phenyl][4-(diethyliminio)-2,5-cyclohexadien-1-ylidene]methyl}-6-hydroxy-1,3-benzenedisulfonate is not hydrolysable.