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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1959-03-16 - 1959-09-07
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study conducted prior to GLP, no guideline followed as none was available in 1959, deficiencies in documentation, no analytical determination of the test concentration, mostly no standard species used.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1959
Report Date:
1959

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Animals were exposed over 4h to the vaporated test item
GLP compliance:
no
Remarks:
test conducted prior to GLP implementation
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: vaporated solid
Details on test material:
- Name of test material (as cited in study report): 2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan
- Substance type: pure substance

Test animals

Species:
other: cat, rabbit, guinea pig, rat, mouse
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
1 cat, 1 rabbit, 1 guinea pig, 2 rats and 4 mice were exposed.

Administration / exposure

Route of administration:
inhalation: mist
Type of inhalation exposure:
whole body
Vehicle:
not specified
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 400 L
- System of generating particulates/aerosols: heating of 20 g of the test item up to 150°C
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
4 h
Concentrations:
2.25 mg/L
No. of animals per sex per dose:
1 cat, 1 rabbit, 1 guinea pig, 2 rats and 4 mice
Control animals:
no
Details on study design:
- Other examinations performed: clinical signs

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 2.25 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: only dose tested, no animal regardless the species died during the study or showed signs of toxicity
Sex:
not specified
Dose descriptor:
LC0
Effect level:
>= 2.25 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: only dose tested, no animal regardless the species died during the study or showed signs of toxicity
Mortality:
none noted
Clinical signs:
no animal regardless the species showed any signs of toxicity

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Criteria used for interpretation of results: expert judgment
Conclusions:
Based on the available data, no absolute classification of the test item is possible. However, it can be stated that it does not need to be classified as acute toxic by inhalation category 1.
Executive summary:

In an acute inhalation toxicity study, 1 cat, 1 rabbit, 1 guinea pig, 2 rats and 4 mice were exposed by inhalation route to 2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan for 4 hours to whole body at a concentration of 2.25 mg/L.

 

LC50> 2.25 mg/L

LC0≥ 2.25 mg/L

No animal regardless the species died during the study or showed signs of toxicity.

 

2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan is classified as being of low toxicity.