2,2'-methylenebis[6-cyclohexyl-p-cresol]

Surface tension

Administrative data

Endpoint:

surface tension

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because water solubility is below 1 mg/L at 20°C

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
The water solubility is 0.034 mg/L (after 72h, at 20 °C) (exp. result, see IUCLID section 4.8, Rheinchemie, 2016).

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

2015-09-25

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

not specified

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

0.034 mg/L

Temp.:

20 °C

pH:

>= 4.9 - <= 6.4

Remarks on result:

other: average of solubilities determined after 24, 48, and 72h shaking

Water solubility:

0.021 mg/L

Temp.:

20 °C

pH:

5.4

Remarks on result:

other: average of solubilities determined after 24h shaking

Water solubility:

0.039 mg/L

Temp.:

20 °C

pH:

6.4

Remarks on result:

other: average of solubilities determined after 48h shaking

Water solubility:

0.041 mg/L

Temp.:

20 °C

pH:

4.9

Remarks on result:

other: average of solubilities determined after 72h shaking

Conclusions:

The water solubility of the test item (CAS 73912-21-7) was determined according to OECD 105 with accetable restrictions, using the flask method, which may be considered as a scientifically reasonable approach, and hence the result of 0.034 mg/L at 20°C can be considered to be reliable. This value is below the limit value of 0.1 mg/L, leading to the classification of the test item as insoluble.

Executive summary:

The water solubility of 2,2'-methylenebis[6-cyclohexyl-p-cresol] was determined to be 0.034 mg/L at 20°C using the shake flask method according to OECD guideline 105 (no GLP).